CAJ | 학술논문

背景:淫羊藿可显著促进体外培养成骨细胞的增殖、分化和成熟,刺激骨形成.目的:观察可注射温敏淫羊藿苷壳聚糖水凝胶修复家兔桡骨骨折愈合的效果.方法:麻醉下将36只兔左右桡骨截断,随机分为实验组、对照组和空白组,前两组分别在骨折端周围注入可注射温敏携淫羊藿苷壳聚糖水凝胶、壳聚糖水凝胶,空白组骨折区未注入任何材料.结果与结论:3组骨折均于术后6周时愈合.X射线片显示,术后2,4,6周,实验组骨折修复区单位面积平均灰度值及成骨细胞计数均明显高于对照组、空白组(P<0.05),且实验组成骨细胞增生活跃.说明可注射温敏携淫羊藿苷壳聚糖水凝胶具有促成骨活性,可促进骨折愈合.
배경:음양곽가현저촉진체외배양성골세포적증식、분화화성숙,자격골형성.목적:관찰가주사온민음양곽감각취당수응효수복가토뇨골골절유합적효과.방법:마취하장36지토좌우뇨골절단,수궤분위실험조、대조조화공백조,전량조분별재골절단주위주입가주사온민휴음양곽감각취당수응효、각취당수응효,공백조골절구미주입임하재료.결과여결론:3조골절균우술후6주시유합.X사선편현시,술후2,4,6주,실험조골절수복구단위면적평균회도치급성골세포계수균명현고우대조조、공백조(P<0.05),차실험조성골세포증생활약.설명가주사온민휴음양곽감각취당수응효구유촉성골활성,가촉진골절유합.
BACKGROUND: Epimedium has in vitro promotive effects on osteoblast osteogenesis, differentiation and maturation. Besides, it can stimulate bone formation. OBJECTIVE:To observe the repair effect of injectable thermo-sensitive icari n chitosan hydrogel on radial fracture healing in rabbits. METHODS:The left and right radius was cut off from 36 rabbits under anesthesia and randomly divided into experimental group, control group and blank group. The rabbits in the former two groups were injected with injectable thermo-sensitive icari n chitosan hydrogel and chitosan hydrogel around the fracture ends, respectively. The rabbits in the blank group had no treatment. RESULTS AND CONCLUSION:Fractures in each group were cured at week 6 after surgery. X-ray films showed that average gray value per unit area and osteoblast count of the experimental group were significantly higher than those of the control and blank groups (P<05). Moreover, the osteoblast proliferation was active in the experimental group. These results suggest that injectable thermo-sensitive icari n chitosan hydrogel can improve osteoblast activity and promote the fracture healing.