中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2012年
43期
7991-7994
,共4页
何芸%陈俊良%刘福祥%古亚兰
何蕓%陳俊良%劉福祥%古亞蘭
하예%진준량%류복상%고아란
Ⅰ型胶原%新型种植体%骨结合%种植体-骨界面%颌骨%生物材料
Ⅰ型膠原%新型種植體%骨結閤%種植體-骨界麵%頜骨%生物材料
Ⅰ형효원%신형충식체%골결합%충식체-골계면%합골%생물재료
背景:刘福祥教授自行设计的新型种植体在较短种植体长度上给出了较大骨接触面积,同时考虑到种植体的抗扭转能力、抗侧向力能力,种植体与骨弹性模量的匹配及加工和植入、修复的便易度.目的:观察自主设计的新型种植体植入颌骨后种植体-骨界面Ⅰ型胶原的表达变化,探讨新型种植体与牙槽骨的骨结合能力.方法:拔除成年狼犬双侧下颌前磨牙3个月后,于两侧拔牙位点牙槽骨分别植入新型种植体和圆柱状种植体各2枚.结果与结论:随时间增加两组周围骨组织密度逐渐升高,新型种植体组圆盘结构间出现密度逐渐升高的影像组织.两组种植体-骨界面均有Ⅰ型胶原表达,均于术后4周达高峰,且新型种植体组术后2,4周Ⅰ型胶原平均灰度值均高于圆柱状种植体组(P<0.05).表明新型种植体植入颌骨后能够取得生物性成功,种植体-骨界面成骨较圆柱状种植体更快,更活跃,骨结合能力更强.
揹景:劉福祥教授自行設計的新型種植體在較短種植體長度上給齣瞭較大骨接觸麵積,同時攷慮到種植體的抗扭轉能力、抗側嚮力能力,種植體與骨彈性模量的匹配及加工和植入、脩複的便易度.目的:觀察自主設計的新型種植體植入頜骨後種植體-骨界麵Ⅰ型膠原的錶達變化,探討新型種植體與牙槽骨的骨結閤能力.方法:拔除成年狼犬雙側下頜前磨牙3箇月後,于兩側拔牙位點牙槽骨分彆植入新型種植體和圓柱狀種植體各2枚.結果與結論:隨時間增加兩組週圍骨組織密度逐漸升高,新型種植體組圓盤結構間齣現密度逐漸升高的影像組織.兩組種植體-骨界麵均有Ⅰ型膠原錶達,均于術後4週達高峰,且新型種植體組術後2,4週Ⅰ型膠原平均灰度值均高于圓柱狀種植體組(P<0.05).錶明新型種植體植入頜骨後能夠取得生物性成功,種植體-骨界麵成骨較圓柱狀種植體更快,更活躍,骨結閤能力更彊.
배경:류복상교수자행설계적신형충식체재교단충식체장도상급출료교대골접촉면적,동시고필도충식체적항뉴전능력、항측향력능력,충식체여골탄성모량적필배급가공화식입、수복적편역도.목적:관찰자주설계적신형충식체식입합골후충식체-골계면Ⅰ형효원적표체변화,탐토신형충식체여아조골적골결합능력.방법:발제성년랑견쌍측하합전마아3개월후,우량측발아위점아조골분별식입신형충식체화원주상충식체각2매.결과여결론:수시간증가량조주위골조직밀도축점승고,신형충식체조원반결구간출현밀도축점승고적영상조직.량조충식체-골계면균유Ⅰ형효원표체,균우술후4주체고봉,차신형충식체조술후2,4주Ⅰ형효원평균회도치균고우원주상충식체조(P<0.05).표명신형충식체식입합골후능구취득생물성성공,충식체-골계면성골교원주상충식체경쾌,경활약,골결합능력경강.
BACKGROUND:The new type implant designed by Professor Liu integrates the character of cylinder implant and blade implant. It is shorter but bigger in contact area. The design of new type implant is considered the torsional capacity, lateral force resisting ability, the match of implant and bone elastic modulus, as wel as processing and implantation and repair convenience. OBJECTIVE:To investigate the changes of typeⅠcolagen expression in the im plant-bone int rfaces after implanted to the jawbone, and to explore the combining capacity of the new type implant and alveolar bone. METHODS:Al the premolars in the bilateral jaw of six adult dogs were extracted. Three months later,two new type implants and two cylinder implants were implanted to the sockets and divided to the new type implants group and cylinder implants group. RESULTS AND CONCLUSION:The density of the guided bone tissue in the two groups was increased with time. The tissues with gradual y increased density in the disk structure of the new type implant group were found. The expression of typeⅠcolagen w as found in the im plant-bone int rface f the two grou s, and both reached the peak at week 4 after surgery. The mean gray value of the new type implant group at weeks 2 and 4 after surgery was higher than that of the cylinder implants group (P<0.05). These findings suggest that new type implant can achieve success after implanted into the jaw bone due to its special design. The osseointegration of the new type implant is earlier, more active and stronger combining capacity than that of the cylinder implant.