CAJ | 학술논문

背景:临床上传统治疗创面感染主要使用抗生素药物敷料,但长期使用会诱导细菌耐药;同时纳米创伤敷料生物相容性差,无法降解,不宜长期覆盖创面.目的:制备一种具有抗菌作用、生物相容性良好的伤口敷料,并表征分析其生物学性能.方法:采用缩醛化反应制得含纳米银/聚乙二醇的壳聚糖/聚乙醇酸海绵,检测材料的物理性能、表面形貌、体外释放及抗菌性能.结果与结论:制得的纳米银粒径小,分散性良好,体外释放实验表明纳米银粒子可持续不断地从辅料释放出来,作用于细菌.含纳米银/聚乙二醇的壳聚糖/聚乙烯醇海绵孔隙致密均匀,大小孔相互贯通;吸水性大、保湿性高、透气性适中;吸水率和透气率都随聚乙烯醇1799含量增加而增大;保湿率基本不变;对金黄色葡萄杆菌、大肠杆菌、白色念珠菌、铜绿假单胞菌、变伤寒沙门菌5种实验菌种均有良好杀菌效果.表明该敷料物理性能好,生物相容性及杀菌效果好.
배경:림상상전통치료창면감염주요사용항생소약물부료,단장기사용회유도세균내약;동시납미창상부료생물상용성차,무법강해,불의장기복개창면.목적:제비일충구유항균작용、생물상용성량호적상구부료,병표정분석기생물학성능.방법:채용축철화반응제득함납미은/취을이순적각취당/취을순산해면,검측재료적물이성능、표면형모、체외석방급항균성능.결과여결론:제득적납미은립경소,분산성량호,체외석방실험표명납미은입자가지속불단지종보료석방출래,작용우세균.함납미은/취을이순적각취당/취을희순해면공극치밀균균,대소공상호관통;흡수성대、보습성고、투기성괄중;흡수솔화투기솔도수취을희순1799함량증가이증대;보습솔기본불변;대금황색포도간균、대장간균、백색념주균、동록가단포균、변상한사문균5충실험균충균유량호살균효과.표명해부료물이성능호,생물상용성급살균효과호.
BACKGROUND:The clinical treatment of traditional wound infection is mainly use antibiotic drugs dressings, but the long-term use can cause bacteria resistance. Meanwhile, nano wound dressings used in clinical application has poor biocompatibility and cannot be degraded, which should not be used for long-term coverage of wound. OBJECTIVE:To prepare a wound dressing with antibacterial action and good biocompatibility, and to characterize and analysis its biological properties. METHODS:Chitosan/polyvinyl alcohol sponge containing nano-silver/polyethyleneglycol was prepared by acetalization reaction. The material’s mechanical properties, surface topography, in vitro release, and antibacterial properties were detected. RESULTS AND CONCLUSION:The particle diameter of nano-silver prepared was smal and it had good disparity. The in vitro release studies showed that Ag nano-silver particles were able to release continuously and sterilize the bacterium. The Chitosan/polyvinyl alcohol sponge containing nano-silver/polyethyleneglycol had dense and uniform interspaces;the pores inside was interconnected, and had favorable moisture-adsorption rate, moisture-retention rate, and moderate air permeability rate. The moisture-adsorption rate and air permeability rate were increased with the content of polyvinyl alcohol 1799 increased, but the moisture-retention rate almost had no effects with the changes of the content of polyvinyl alcohol 1799. The material had a good bactericidal effect on the staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and salmonel a typhi. These findings suggest that the dressing not only possesses good physical properties and anti-microbial, but also its synthesis procedure is simple and low cost. Therefore, the developed material can be applied to new wound dressing.