CAJ | 학술논문

背景:磁悬浮离心血心室辅助装置独特的心尖插管设计,可以在心脏不停跳状态下完成左心室插管,明显缩短手术时间,避免体外循环的有害影响.目的:验证磁悬浮驱动离心式左心室辅助装置的在体可靠性.方法:将磁悬浮驱动离心式左心室辅助装置装置入口通过不停跳方式植入绵羊左心尖,出口与降主动脉吻合.手术前后行全血、生化以及血凝检查,期间不间断采集与辅助装置主体血心室辅助装置功能相关的数据,并做主要脏器宏观和病理检查.结果与结论:在体辅助38 d期间辅助装置无机械故障发生,心室辅助装置的流入和流出道未见血栓沉积,血液和生化检查结果均在正常范围.实验羊无明显并发症,主要脏器宏观和病理检查表明无缺血或梗死.证实磁悬浮驱动离心式左心室辅助装置具有良好的在体血液相容性和可靠性.
배경:자현부리심혈심실보조장치독특적심첨삽관설계,가이재심장불정도상태하완성좌심실삽관,명현축단수술시간,피면체외순배적유해영향.목적:험증자현부구동리심식좌심실보조장치적재체가고성.방법:장자현부구동리심식좌심실보조장치장치입구통과불정도방식식입면양좌심첨,출구여강주동맥문합.수술전후행전혈、생화이급혈응검사,기간불간단채집여보조장치주체혈심실보조장치공능상관적수거,병주주요장기굉관화병리검사.결과여결론:재체보조38 d기간보조장치무궤계고장발생,심실보조장치적류입화류출도미견혈전침적,혈액화생화검사결과균재정상범위.실험양무명현병발증,주요장기굉관화병리검사표명무결혈혹경사.증실자현부구동리심식좌심실보조장치구유량호적재체혈액상용성화가고성.
BACKGROUND:The unique apex intubation design of a magnetic suspension centrifugal ventricular assist device can finish left ventricular intubation with heart beating, which significantly shortens the operative time and avoids the harmful effects of cardiopulmonary bypass. OBJECTIVE:To verify the in vivo reliability of the magnetic suspension centrifugal left ventricular assist device. METHODS:The magnetic suspension centrifugal left ventricular assist device was implanted into the left ventricular apex of a healthy sheep with heart beating. The outflow graft of each device was anastomosed to the descending aorta. Hematologic, biochemical and blood clotting tests before and after surgery were performed on schedule. Data associated with pump function were col ected continuously, and the end-organs were examined macroscopical y and histopathological y. RESULTS AND CONCLUSION:During the in vivo assisted 38 days, no mechanical wearing and the thrombus formation at inflow and outflow were observed inside the pump. Hematologic and biochemical test results were within the normal range. There were no significant complications in the sheep. Macroscopical and histopathological examination of the end organs revealed no evidence of ischemia or infarction. These findings suggest that the magnetic suspension centrifugal left ventricular assist device has good in vivo hemocompatibility and reliability.