CAJ | 학술논문

背景:目前以钴铬合金为基础的冠状动脉内药物洗脱支架不能从根本上解决亚急性血栓形成和再狭窄问题,于是生物可吸收支架成为关注的焦点.目的:评估自行设计制作冠状动脉内可吸收镁合金支架的生物相容性、有效性和安全性.方法:35只犬均于冠状动脉和/或股动脉置入可吸收镁合金支架1枚,分别于支架置入后24 h、3 d、5 d、1周、2周、3周、4周(n=5)复查冠状动脉及血管造影后取材,分离支架段血管行组织病理观察及计算机图像分析,测量内弹力板面积、管腔面积、内膜增生面积及内膜增生面积百分比.结果与结论:51枚支架成功置入35只犬的冠状动脉和股动脉,支架置入后不同时点各组冠状动脉及股动脉造影均证实管腔通畅,无狭窄病变,无血栓形成,置入后1周左右支架完全降解.组织病理学结果显示,支架置入后2周开始出现轻微内膜增生,内膜增生面积百分比随着时间的推移逐渐增高.提示自行研发的冠状动脉内可吸收镁合金支架1周内降解,置入早期未见明显炎症反应及血栓形成,再狭窄程度轻,具有良好的生物相容性,安全有效.
배경:목전이고락합금위기출적관상동맥내약물세탈지가불능종근본상해결아급성혈전형성화재협착문제,우시생물가흡수지가성위관주적초점.목적:평고자행설계제작관상동맥내가흡수미합금지가적생물상용성、유효성화안전성.방법:35지견균우관상동맥화/혹고동맥치입가흡수미합금지가1매,분별우지가치입후24 h、3 d、5 d、1주、2주、3주、4주(n=5)복사관상동맥급혈관조영후취재,분리지가단혈관행조직병리관찰급계산궤도상분석,측량내탄력판면적、관강면적、내막증생면적급내막증생면적백분비.결과여결론:51매지가성공치입35지견적관상동맥화고동맥,지가치입후불동시점각조관상동맥급고동맥조영균증실관강통창,무협착병변,무혈전형성,치입후1주좌우지가완전강해.조직병이학결과현시,지가치입후2주개시출현경미내막증생,내막증생면적백분비수착시간적추이축점증고.제시자행연발적관상동맥내가흡수미합금지가1주내강해,치입조기미견명현염증반응급혈전형성,재협착정도경,구유량호적생물상용성,안전유효.
BACKGROUND:At present, the subacute thrombosis and restenosis cannot be fundamental y resolved by the local drug-eluting stent which is based on cobalt-chromium al oy in the coronary artery. Therefore, the bio-absorbable stents have become the focus. OBJECTIVE:To evaluate the biocompatibility, effectiveness and safety of absorbable magnesium al oy stents in the coronary artery. METHODS:Total y 35 immunized hybrid dogs were al implanted an absorbable magnesium al oy stent in the coronary artery and/or the femoral artery. Each dog received the coronary and femoral angiography after implantation for 24 hours, 3 days, 5 days, 1 week, 2 weeks, 3 weeks and 4 weeks respectively. And then the stent arteries were isolated for histopathological analysis and computer image analysis, besides, the elastic lamina area, lumen area, and the percentage of intimal hyperplasia area were measured. RESULTS AND CONCLUSION:Fifty-one stents were implanted in 35 dog’s coronary and femoral arteries successful y. The angiography of the coronary and femoral arteries at different time points after implantation was found the clear lumen, as wel as no constriction and thrombosis;besides, the stent was completely degraded at 1 week after implantation. The results of histopathological analysis showed that there was a slight intimal hyperplasia at week 2 after implantation, and the percentage of hyperplasia area was increased with time. These findings suggest that the absorbable magnesium al oy stent in the coronary artery can be degraded within 1 week, and no significant inflammatory response and thrombosis formation were found, what’s more, restenosis degree was slight. Therefore, this kind of stent has good biocompatibility, effectiveness and safety.