CAJ | 학술논문

背景:血清肿瘤坏死因子α和白细胞介素1β作为炎症递质,其水平与骨性关节炎病情相关.而骨髓间充质干细胞治疗骨性关节炎报道较少. 目的:用骨髓间充质干细胞治疗兔早期骨性关节炎,观察关节软骨 T2值及血清肿瘤坏死因子α和白细胞介素1β水平并进行分析. 方法:将36只新西兰大白兔随机均分成对照组、模型组和治疗组.模型组兔仅建立骨性关节炎模型,治疗组在造模后第4周左膝关节腔内注射骨髓间充质干细胞;对照组膝关节腔内注射等量生理盐水.分别在治疗后第2周,1,2,3个月行左后膝关节核磁共振及血清肿瘤坏死因子α和白细胞介素1β水平检查. 结果与结论:与模型组比较,治疗组 T2值降低,无关节腔积液;血清肿瘤坏死因子α和白细胞介素1β水平降低;软骨 T2值变化与二者呈正相关.MRI 能够反映早期关节软骨的生物学改变,可用于评价骨性关节炎治疗前后的改变;骨髓间充质干细胞在关节腔内可向软骨分化,为早期骨性关节炎患者提供了一种新的有效疗法.
배경:혈청종류배사인자α화백세포개소1β작위염증체질,기수평여골성관절염병정상관.이골수간충질간세포치료골성관절염보도교소. 목적:용골수간충질간세포치료토조기골성관절염,관찰관절연골 T2치급혈청종류배사인자α화백세포개소1β수평병진행분석. 방법:장36지신서란대백토수궤균분성대조조、모형조화치료조.모형조토부건립골성관절염모형,치료조재조모후제4주좌슬관절강내주사골수간충질간세포;대조조슬관절강내주사등량생리염수.분별재치료후제2주,1,2,3개월행좌후슬관절핵자공진급혈청종류배사인자α화백세포개소1β수평검사. 결과여결론:여모형조비교,치료조 T2치강저,무관절강적액;혈청종류배사인자α화백세포개소1β수평강저;연골 T2치변화여이자정정상관.MRI 능구반영조기관절연골적생물학개변,가용우평개골성관절염치료전후적개변;골수간충질간세포재관절강내가향연골분화,위조기골성관절염환자제공료일충신적유효요법.
BACKGROUND: Serum tumor necrosis factor α and interleukin-1β as an inflammatory mediator is related to the condition of osteoarthritis. However, the reports on the treatment of osteoarthritis by bone marrow mesenchymal stem cel s are rare. OBJECTIVE: To observe the T2 value, the serum tumor necrosis factor α and interleukin-1β levels in the treatment of early osteoarthritis in rabbits by bone marrow mesenchymal stem cel s transplantation. @@@@METHODS: Thirty-six New Zealand white rabbits were randomly and equal y divided into control group, model group and treatment group. Rabbits in the model group were only used to establish the osteoarthritis model; left knee joint cavity of rabbits in the treatment group was injected with bone marrow mesenchymal stem cel s at 4 weeks after modeling; knee joint cavity of rabbits in the control group was injected with normal saline in the same dose. Left knee joint magnetic resonance imaging and the detection of serum tumor necrosis factor α and interleukin-1β levels were performed at 2 weeks, 1, 2 and 3 months after treatment. @@@@RESULTS AND CONCLUSION: Compared with the meodel group, the T2 value reduced, without arthroedema, and the serum tumor necrosis factor α and interleukin-1β levels were decreased in the treatment group. The T2 value was positive correlated with serum tumor necrosis factor α and interleukin-1β levels. MRI can reflect the early biological y change of articular cartilage, and it can be used to evaluate the curative effect in the early stages of osteoarthritis. Bone marrow mesenchymal stem cel s can differentiate into chondrocytes in articular cavity and is effective for early