CAJ | 학술논문

背景:骨质疏松、吸烟可致口腔种植失败率显著增高.目的:观察雌激素对吸烟骨质疏松大鼠种植体周围骨沉积的影响.方法:50只雌性大鼠均分为5组:除假手术组外,卵巢去势组、卵巢去势+雌激素组、卵巢去势+吸烟组、卵巢去势+吸烟+雌激素组均制备卵巢去势模型,去势术后后两组持续熏烟24周.去势术后12周,在大鼠右侧胫骨近骺端植入钛种植体,种植后对卵巢去势+雌激素组和卵巢去势+吸烟+雌激素组肌注雌激素.实验24周时行动物活体骨密度测量及 X 射线观察,处死动物采集标本行种植体骨硬组织切片观察.结果与结论:骨密度及 X 射线观察结果显示,雌激素可提高种植体周围骨沉积.硬组织切片观察结果显示,卵巢去势+雌激素组种植体骨包绕范围基本形成骨结合,松质骨区结合骨板与周围骨小梁相连.卵巢去势+吸烟+雌激素组种植体周围结合骨板较卵巢去势+吸烟组明显增厚,骨板周围小梁骨增多.提示雌激素可在一定程度上提高吸烟骨质疏松大鼠种植体周围骨沉积,促进种植体骨结合.
배경:골질소송、흡연가치구강충식실패솔현저증고.목적:관찰자격소대흡연골질소송대서충식체주위골침적적영향.방법:50지자성대서균분위5조:제가수술조외,란소거세조、란소거세+자격소조、란소거세+흡연조、란소거세+흡연+자격소조균제비란소거세모형,거세술후후량조지속훈연24주.거세술후12주,재대서우측경골근후단식입태충식체,충식후대란소거세+자격소조화란소거세+흡연+자격소조기주자격소.실험24주시행동물활체골밀도측량급 X 사선관찰,처사동물채집표본행충식체골경조직절편관찰.결과여결론:골밀도급 X 사선관찰결과현시,자격소가제고충식체주위골침적.경조직절편관찰결과현시,란소거세+자격소조충식체골포요범위기본형성골결합,송질골구결합골판여주위골소량상련.란소거세+흡연+자격소조충식체주위결합골판교란소거세+흡연조명현증후,골판주위소량골증다.제시자격소가재일정정도상제고흡연골질소송대서충식체주위골침적,촉진충식체골결합.
BACKGROUND: Osteoporosis and smoking can increase dental implant failure rate significantly. OBJECTIVE: To investigate the effect of estrogen on bone deposition around implants in osteoporosis rats undergoing cigarette smoke inhalation. METHODS: Fifty 3-month-old female SD rats were randomly divided into five groups (n=10): sham operation group, ovariectomy group, ovariectomy+smoke inhalation group, ovariectomy+estrogen group and ovariectomy+smoke inhalation+estrogen group. Rats in al groups were subjected to ovariectomy except the sham operation group. After ovariectomy, the latter two groups were given cigarette smoke inhalation for 24 weeks. Then, screw-type titanium implants were placed into the right tibiae in rats at 12 weeks after ovariectomy or sham surgery. Next, rats in the ovariectomy+estrogen group and ovariectomy+smoke inhalation+estrogen group were injected with estradiol benzoate intramuscularly. After 24 weeks, before sacrificed, densitometry of the tibiae in rats was detected by X-ray test. After that the samples of dead rats were col ected and the tibiae with implant were removed by hand-mil piece of bone implant for observation. RESULTS AND CONCLUSION: The densitometry and X-ray results demonstrated that estradiol could improve bone deposition around implants. Hard tissue slicing observations result showed that in ovariectomy+estrogen group, the implants obtained good osseointegration, besides, cancel ous bone area combined with bone lamel a was connected with the trabecular bone. In addition, the bonding bone lamel a in ovariectomy+smoke inhalation+estrogen group was thicker than that in ovariectomy+smoke inhalation group. Moreover, the amount of trabecular bone was increased. These results suggest that estrogen can improve the bone deposition around implants to a certain extent and promote implant osseointegration in osteoporosis rats undergoing cigarette smoke inhalation.