CAJ | 학술논문

背景:引导骨再生对于成骨的引导及成形效果在基础研究及动物实验中已得到充分肯定,但国内有关人的颌骨骨缺损后引导骨再生中新生骨的组织学观察是一个空白.目的:应用组织学检查了解人引导骨再生修复颌骨骨缺损的成骨效果.方法:选取引导骨再生治疗颌骨骨缺损患者19例24个部位,于治疗后6个月行种植术中,中空钻取出术区新生骨,组织学观察,评价成骨效果.结果与结论:所取新生骨可见不同发育阶段的骨形成.近根尖段骨中主要为板层骨,而冠方新生骨主要为纤维性骨形成,内含类骨组织及软骨性骨,极少板层骨.提示人颌骨骨缺损经引导骨再生后6个月成骨效果肯定,但远期效果还有待进一步观察.
배경:인도골재생대우성골적인도급성형효과재기출연구급동물실험중이득도충분긍정,단국내유관인적합골골결손후인도골재생중신생골적조직학관찰시일개공백.목적:응용조직학검사료해인인도골재생수복합골골결손적성골효과.방법:선취인도골재생치료합골골결손환자19례24개부위,우치료후6개월행충식술중,중공찬취출술구신생골,조직학관찰,평개성골효과.결과여결론:소취신생골가견불동발육계단적골형성.근근첨단골중주요위판층골,이관방신생골주요위섬유성골형성,내함류골조직급연골성골,겁소판층골.제시인합골골결손경인도골재생후6개월성골효과긍정,단원기효과환유대진일보관찰.
BACKGROUND: Osteogenesis effects of guided bone regeneration have been verified in basic research and animal experiments. However, histological observation of bone regeneration fol owing repair of human mandibular bone defects using guided bone regeneration is not reported in China. OBJECTIVE: To study the osteogenesis effects of guided bone regeneration on the repair of human mandibular bone defects through histological observation. METHODS: Twenty-four defects from 19 mandibular bone defect patients were subjected to guided bone regeneration therapy. After 6 months, dental implantation was performed. New bone tissues in the surgical area were taken using a hol ow dril for histological observation and osteogenesis evaluation. RESULTS AND CONCLUSION: Different developmental stages of bone formation were visible in new bone tissues. Lamel ar bone tissues were mainly found near the root apex, while fibrous bone tissues containing osteoid tissue and cartilage bone formed at the dental crown. It indicated that there is a certain 6-month osteogenesis effect of guided bone regeneration, but the long-term effect needs further observation.