CAJ | 학술논문

背景:目前有关生物源性和无机骨组织替代材料的研究时有报道,但是选择这两种材料对于颅骨缺损病理改变的骨增量和成骨效果的差异尚无定论.目的:比较兔颅骨缺损再生修复中应用生物源性和无机源性骨组织替代材料引导骨组织再生的能力.方法:建立成年新西兰兔颅顶骨3个直径8 mm 洞型骨缺损模型,前方和后方洞型骨缺损区分别采用无机源性Bio-Oss 骨粉与生物源性天博固齿骨粉填充并用胶原生物膜覆盖.中间洞型骨缺损区仅用胶原生物膜覆盖不做其他处理,作为对照组.结果与结论:术后12,16,24周通过 Masson 三色染色图像分析显示,无机源性骨粉组和生物源性骨粉组较空白对照组新生骨量明显增加,且生物源性骨粉组新生骨量明显多于无机源性骨粉组(P ≤0.05).可见无机源性与生物源性骨粉均可起到引导新骨再生修复骨缺损的作用,但生物源性骨粉修复骨缺损效果优于无机源性骨粉.
배경:목전유관생물원성화무궤골조직체대재료적연구시유보도,단시선택저량충재료대우로골결손병리개변적골증량화성골효과적차이상무정론.목적:비교토로골결손재생수복중응용생물원성화무궤원성골조직체대재료인도골조직재생적능력.방법:건립성년신서란토로정골3개직경8 mm 동형골결손모형,전방화후방동형골결손구분별채용무궤원성Bio-Oss 골분여생물원성천박고치골분전충병용효원생물막복개.중간동형골결손구부용효원생물막복개불주기타처리,작위대조조.결과여결론:술후12,16,24주통과 Masson 삼색염색도상분석현시,무궤원성골분조화생물원성골분조교공백대조조신생골량명현증가,차생물원성골분조신생골량명현다우무궤원성골분조(P ≤0.05).가견무궤원성여생물원성골분균가기도인도신골재생수복골결손적작용,단생물원성골분수복골결손효과우우무궤원성골분.
BACKGROUND: At present, there are several reports about studies on bio-derived and inorganic-derived bone tissue substitutes. But the difference between the two bone materials in bone augmentation guided by calvarial defects and osteogenic effects is debatable. OBJECTIVE: To compare the ability of guiding new bone regeneration between the two bone materials during the repair of calvarial defects in rabbits. METHODS: A rabbit model of calvarial defects with three 8 mm diameter holes was established. The front and rear bone defects areas were fil ed separately with inorganic-derived and bio-derived bone materials. The middle bone defects areas were only covered with col agen membranes as a control. RESULTS AND CONCLUSION: At weeks 12, 16 and 24 after treatment, the Masson’s trichrome staining image showed that the new bone quantity of the two bone materials was obviously more than that of the blank control group at each time point; and the new bone quantity in the bio-derived bone materials group was obviously more than that of the inorganic-derived bone materials group at each time point (P ≤ 0.05). These results suggest that inorganic-derived and bio-derived bone materials can both guide new bone regeneration for repairing bone defects, but the effectiveness of bio-derived bone materials is superior to that of the inorganic-derived bone materials.