中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2012年
48期
9059-9063
,共5页
关节置换%磨损颗粒%无菌性%松动%研究进展
關節置換%磨損顆粒%無菌性%鬆動%研究進展
관절치환%마손과립%무균성%송동%연구진전
背景:研究显示磨损颗粒诱导的假体周围骨溶解是导致人工假体无菌性松动的最主要原因.目的:对磨损颗粒引起人工关节假体无菌性松动在分子生物学方面的研究现状及新进展作一综述.方法:应用计算机检索 CNKI 和 Pubmed 数据库中1991年1月至2012年3月关于人工关节磨损颗粒的文章,在标题和中以“关节置换,磨损颗粒,假体松动”或“arthroplasty,wear particles,loosening of the prosthesis”为检索词进行检索.最终选择30篇文献进行综述.结果与结论:假体无菌性松动是人工关节置换后手术失败的最主要原因,在此过程中磨损颗粒起到关键性作用.通过对细胞因子及信号传导途径研究的综述,为预防及药物治疗假体无菌性松动提供理论依据.然而,假体的无菌性松动受多种因素的影响,所以预防应从整体着眼,全面深入研究,为假体的松动防治提供方向.
揹景:研究顯示磨損顆粒誘導的假體週圍骨溶解是導緻人工假體無菌性鬆動的最主要原因.目的:對磨損顆粒引起人工關節假體無菌性鬆動在分子生物學方麵的研究現狀及新進展作一綜述.方法:應用計算機檢索 CNKI 和 Pubmed 數據庫中1991年1月至2012年3月關于人工關節磨損顆粒的文章,在標題和中以“關節置換,磨損顆粒,假體鬆動”或“arthroplasty,wear particles,loosening of the prosthesis”為檢索詞進行檢索.最終選擇30篇文獻進行綜述.結果與結論:假體無菌性鬆動是人工關節置換後手術失敗的最主要原因,在此過程中磨損顆粒起到關鍵性作用.通過對細胞因子及信號傳導途徑研究的綜述,為預防及藥物治療假體無菌性鬆動提供理論依據.然而,假體的無菌性鬆動受多種因素的影響,所以預防應從整體著眼,全麵深入研究,為假體的鬆動防治提供方嚮.
배경:연구현시마손과립유도적가체주위골용해시도치인공가체무균성송동적최주요원인.목적:대마손과립인기인공관절가체무균성송동재분자생물학방면적연구현상급신진전작일종술.방법:응용계산궤검색 CNKI 화 Pubmed 수거고중1991년1월지2012년3월관우인공관절마손과립적문장,재표제화중이“관절치환,마손과립,가체송동”혹“arthroplasty,wear particles,loosening of the prosthesis”위검색사진행검색.최종선택30편문헌진행종술.결과여결론:가체무균성송동시인공관절치환후수술실패적최주요원인,재차과정중마손과립기도관건성작용.통과대세포인자급신호전도도경연구적종술,위예방급약물치료가체무균성송동제공이론의거.연이,가체적무균성송동수다충인소적영향,소이예방응종정체착안,전면심입연구,위가체적송동방치제공방향.
BACKGROUND: Studies have shown that the wear particle-induced periprosthesis osteolysis is the main reason leading to aseptic loosening of prosthesis. OBJECTIVE: To review the research progress of the wear particle-induced aseptic prosthesis loosening in molecular biology. METHODS: A computer-based search was performed on the CNKI database and PubMed database from January 1991 to March 2012 for the articles related to the wear particles of prosthesis. The key words of “arthroplasty, wear particles, loosening of the prosthesis” in English and Chinese were used to search the articles in the title and the abstract. Final y, a total of 30 artilces were included to review. RESULTS AND CONCLUSION: Aseptic loosening of the prosthesis is the main reason for the failure of the surgery after artificial joint replacement, and the wear particles play an important role during the process. The synthesis on the research of cytokines and signal transduction pathways provides a theoretical basis for prevention and drug treatment of prosthesis aseptic loosening. However, prosthesis aseptic loosening can be influenced by a variety of factors, prevention should be the overal focused and comprehensive studied which can provide direction for the prevention of prosthesis loosening .
