CAJ | 학술논문

背景:由骨髓增生异常综合征转化的急性白血病为难治白血病,临床疗效差,缓解率低,生存期短,因此探索新的有效治疗方法极为重要.目的:观察地西他滨联合造血干细胞移植治疗骨髓增生异常综合征转化急性白血病的临床疗效及并发症.方法:骨髓增生异常综合征转化的急性髓细胞白血病患者1例,先后予2个疗程地西他滨及异基因造血干细胞移植,观察临床疗效、地西他滨的毒副作用及移植相关并发症.结果与结论:经2个疗程地西他滨治疗后,达到完全缓解,主要不良反应为骨髓抑制并发感染,该患者再接受异基因造血干细胞移植后获得无病生存213 d,移植过程中出现急性移植物抗宿主病及肺部感染.结果提示地西他滨联合造血干细胞移植治疗骨髓增生异常综合征转化急性白血病获得良好效果,毒副作用及相关并发症可控制,为临床上骨髓增生异常综合征转化急性白血病的治疗提供了新方法.
배경:유골수증생이상종합정전화적급성백혈병위난치백혈병,림상료효차,완해솔저,생존기단,인차탐색신적유효치료방법겁위중요.목적:관찰지서타빈연합조혈간세포이식치료골수증생이상종합정전화급성백혈병적림상료효급병발증.방법:골수증생이상종합정전화적급성수세포백혈병환자1례,선후여2개료정지서타빈급이기인조혈간세포이식,관찰림상료효、지서타빈적독부작용급이식상관병발증.결과여결론:경2개료정지서타빈치료후,체도완전완해,주요불량반응위골수억제병발감염,해환자재접수이기인조혈간세포이식후획득무병생존213 d,이식과정중출현급성이식물항숙주병급폐부감염.결과제시지서타빈연합조혈간세포이식치료골수증생이상종합정전화급성백혈병획득량호효과,독부작용급상관병발증가공제,위림상상골수증생이상종합정전화급성백혈병적치료제공료신방법.
BACKGROUND:Acute leukemia progressed from myelodysplastic syndrome is a refractory disease with poor clinical therapeutic effect, low remission rate and short survival period. Therefore, it is extremely important to explore a new and effective treatment method. OBJECTIVE:To investigate the clinical therapeutic effects and complications of decitabine application combined with al ogeneic hematopoietic stem cel transplantation in treatment of acute leukemia progressed from myelodysplastic syndrome. METHODS:One patient with acute leukemia progressed from myelodysplastic syndrome received two courses of decitabine application combined with al ogeneic hematopoietic stem cel transplantation. Clinical curative effects, the side effects of decitabine and the complications of al ogeneic hematopoietic stem cel transplantation were investigated. RESULTS AND CONCLUSION:The patient achieved complete remission after two courses of decitabine application combined with al ogeneic hematopoietic stem cel transplantation with infection and myelosuppresison. The patient lived without disease for 213 days although acute graft-versus-host disease and pulmonary infection occurred after decitabine application combined with al ogeneic hematopoietic stem cel transplantation. These findings suggest that decitabine application combined with al ogeneic hematopoietic stem cel transplantation is an effective method to treat acute leukemia progressed from myelodysplastic syndrome, and the side effects and complications can be wel control ed.