CAJ | 학술논문

背景:有研究表明脂肪来源干细胞具有组织修复能力,但将其应用于面部年轻化治疗中的报道较少.目的:将原代脂肪来源干细胞辅助颗粒脂肪移植,联合颞部小切口除皱术应用于接受面部年轻化治疗的患者,观察该治疗方法的临床效果.方法:回顾分析解放军沈阳军区总医院整形外在2009年6月至2011年8月的20例来院接受面部除皱治疗女性患者的资料.其中接受自体脂肪来源干细胞辅助治疗的患者10例设为治疗组,单纯接受除皱术患者10例设为对照组.采用皱纹评分的方法,结合VISIA专业皮肤图像分析系统对患者治疗后的斑点、毛孔、皱纹、纹理进行检测,对所得数据进行比较分析.结果与结论:治疗后随访3-15个月,两组治疗前后皱纹评分差异无显著性意义,说明两组治疗患者在皱纹的改善方面效果没有明显区别.治疗前、后的VISIA皮肤检测结果显示,治疗组的毛孔和斑点改善率优于对照组(P<0.05),纹理和皱纹改善率差异无显著性意义(P>0.05).证实,脂肪来源干细胞辅助下的面部年轻化治疗与单纯除皱疗法在面部年轻化治疗的除皱效果基本一致,但治疗后患者的皮肤毛孔、斑点改善效果明显更好.
배경:유연구표명지방래원간세포구유조직수복능력,단장기응용우면부년경화치료중적보도교소.목적:장원대지방래원간세포보조과립지방이식,연합섭부소절구제추술응용우접수면부년경화치료적환자,관찰해치료방법적림상효과.방법:회고분석해방군침양군구총의원정형외재2009년6월지2011년8월적20례래원접수면부제추치료녀성환자적자료.기중접수자체지방래원간세포보조치료적환자10례설위치료조,단순접수제추술환자10례설위대조조.채용추문평분적방법,결합VISIA전업피부도상분석계통대환자치료후적반점、모공、추문、문리진행검측,대소득수거진행비교분석.결과여결론:치료후수방3-15개월,량조치료전후추문평분차이무현저성의의,설명량조치료환자재추문적개선방면효과몰유명현구별.치료전、후적VISIA피부검측결과현시,치료조적모공화반점개선솔우우대조조(P<0.05),문리화추문개선솔차이무현저성의의(P>0.05).증실,지방래원간세포보조하적면부년경화치료여단순제추요법재면부년경화치료적제추효과기본일치,단치료후환자적피부모공、반점개선효과명현경호.
BACKGROUND:Several studies have demonstrated that adipose-derived stem cel s have tissue reparative ability, but few studies have been reported about application of adipose-derived stem cel s in facial rejuvenation treatment. OBJECTIVE:Primary adipose-derived stem cel s were isolated from human liposuction aspirates and added into adipose tissue. The compounds were injected into the face of patients who underwent face lifting through tempus incision. The aesthetic effects were observed. METHODS:Clinical data of 20 female patients who underwent fact lifting between June 2009 and August 2011 in Department of Plastic Surgery, General Hospital of Shenyang Military Command were retrospectively analyzed. Ten patients who received autologous adipose-derived stem cel s assisted treatment were included in the treatment group, and the remaining 10 patients who underwent simple facial lifting were included in the control group. The therapeutic effects were evaluated using score of wrinkle standard and VISIA professional skin image analysis system in terms of freckle, pores, wrinkle, and skin texture. RESULTS AND CONCLUSION:Twenty patients were fol owed by 3-15 months. There was no significant difference in the score of wrinkle standard between treatment and control groups (P>0.05). It suggests that autologous adipose-derived stem cel s assisted treatment and simple face lifting have no obvious difference in reducing the wrinkles. VISIA skin detection results showed that there was a greater improvement in freckle and pores in the treatment group compared with the control group (P<0.05) and there was no significant difference in improvement in skin texture and wrinkles (P>0.05). These results suggest that autologous adipose-derived stem cel s assisted treatment and simple face lifting have similar effects in facial rejuvenation, but the former exhibits better effects than the latter one on improving pores and freckle.