中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2012年
49期
271-275
,共5页
骨髓间充质干细胞%骨组织工程%骨缺损%成骨细胞%综述文献
骨髓間充質榦細胞%骨組織工程%骨缺損%成骨細胞%綜述文獻
골수간충질간세포%골조직공정%골결손%성골세포%종술문헌
背景:在一定条件下骨髓间充质干细胞具有分化为成骨细胞、软骨细胞的特性,成为骨组织工程中研究最为深入的种子细胞.目的:对骨髓间充质干细胞在骨缺损中的基础研究与临床应用进展作一综述.方法:应用计算机检索CNKI和Pubmed数据库中1999年1月至2012年1月关于骨髓间充质干细胞应用于骨缺损治疗的文章,在标题和中以“骨髓间充质干细胞,骨缺损”或“ Bone mesenchymal stem cel s,bone defect”为检索词进行检索.选择文章内容与骨髓间充质干细胞治疗骨缺损有关者,同一领域文献则选择近期发表或发表在权威杂志文章.最终选择30篇文献进行综述.结果与结论:骨髓间充质干细胞分离获取方法成熟,具有成骨细胞定向诱导分化能力,能有效地进行骨质缺损修复,尤其随着生物支架材料和基因工程技术的发展,骨髓间充质干细胞在骨缺损治疗中的应用必将更加广泛.
揹景:在一定條件下骨髓間充質榦細胞具有分化為成骨細胞、軟骨細胞的特性,成為骨組織工程中研究最為深入的種子細胞.目的:對骨髓間充質榦細胞在骨缺損中的基礎研究與臨床應用進展作一綜述.方法:應用計算機檢索CNKI和Pubmed數據庫中1999年1月至2012年1月關于骨髓間充質榦細胞應用于骨缺損治療的文章,在標題和中以“骨髓間充質榦細胞,骨缺損”或“ Bone mesenchymal stem cel s,bone defect”為檢索詞進行檢索.選擇文章內容與骨髓間充質榦細胞治療骨缺損有關者,同一領域文獻則選擇近期髮錶或髮錶在權威雜誌文章.最終選擇30篇文獻進行綜述.結果與結論:骨髓間充質榦細胞分離穫取方法成熟,具有成骨細胞定嚮誘導分化能力,能有效地進行骨質缺損脩複,尤其隨著生物支架材料和基因工程技術的髮展,骨髓間充質榦細胞在骨缺損治療中的應用必將更加廣汎.
배경:재일정조건하골수간충질간세포구유분화위성골세포、연골세포적특성,성위골조직공정중연구최위심입적충자세포.목적:대골수간충질간세포재골결손중적기출연구여림상응용진전작일종술.방법:응용계산궤검색CNKI화Pubmed수거고중1999년1월지2012년1월관우골수간충질간세포응용우골결손치료적문장,재표제화중이“골수간충질간세포,골결손”혹“ Bone mesenchymal stem cel s,bone defect”위검색사진행검색.선택문장내용여골수간충질간세포치료골결손유관자,동일영역문헌칙선택근기발표혹발표재권위잡지문장.최종선택30편문헌진행종술.결과여결론:골수간충질간세포분리획취방법성숙,구유성골세포정향유도분화능력,능유효지진행골질결손수복,우기수착생물지가재료화기인공정기술적발전,골수간충질간세포재골결손치료중적응용필장경가엄범.
BACKGROUND:Bone marrow mesenchymal stem cel s have multilineage differentiation potential, which can be induced to differentiate into osteoblasts and chondrocytes under special conditions in vitro or in vivo. They are widely used for bone tissue engineering. OBJECTIVE:To review the basic research and clinical application of bone marrow mesenchymal stem cel s for repair of bone defects. METHODS:The CNKI database and PubMed database (1999-01/2012-01) were used to search the related articles about the application of bone marrow mesenchymal stem cel s for repair of bone defects. The key words are“bone marrow mesenchymal stem cel s, bone defect”. Articles concerning bone marrow mesenchymal stem cel s for the treatment of bone defects were included. For the articles that published recently or in the high-impact journals were preferred, and articles with repetitive contents were ruled out. Then 30 articles were suitable for further analysis. RESULTS AND CONCLUSION:Bone marrow mesechymal stem cel s can be easily isolated from bone marrow. Bone marrow mesenchymal stem cel s can be used to repair bone defects effectively because of their ability to differentiate into osteoblasts, especial y with the development of biological scaffold materials and gene engineering technology.
