CAJ | 학술논문

背景:研究表明他汀类药物具有刺激骨新生的作用. 目的:观察辛伐他汀/甲基纤维素凝胶对小型猪根分叉区牙槽骨缺损后骨再生的影响. 方法:制备小型猪上下颌两侧第三、四前磨牙Ⅱ度根分叉牙槽骨缺损模型,随机分为5组:低、中、高浓度辛伐他汀/甲基纤维素凝胶组于人工根分叉缺损处分别注射0.01,0.03,0.044 g/mL辛伐他汀/甲基纤维素凝胶50μL,对照组于人工根分叉缺损处注射甲基纤维素凝胶50μL,1次/周,连续8周;空白对照组不作任何处理. 结果与结论:与对照组和空白对照组比较,低、中、高浓度辛伐他汀/甲基纤维素凝胶组根分叉区牙槽骨高度明显修复(P<0.001),新生牙槽骨几乎充满根分叉区,可见骨小梁成网状结构及成熟的哈佛氏系统,其中低浓度辛伐他汀/甲基纤维素凝胶组新生骨成熟度较中、高浓度辛伐他汀/甲基纤维素凝胶组高,且炎症细胞浸润较少.对照组与空白对照组未见明显新生骨,仅见少量新生骨.表明局部应用辛伐他汀/甲基纤维素凝胶可刺激根分叉区牙槽骨缺损后的骨再生,适宜剂量是0.01 g/mL.
배경:연구표명타정류약물구유자격골신생적작용. 목적:관찰신벌타정/갑기섬유소응효대소형저근분차구아조골결손후골재생적영향. 방법:제비소형저상하합량측제삼、사전마아Ⅱ도근분차아조골결손모형,수궤분위5조:저、중、고농도신벌타정/갑기섬유소응효조우인공근분차결손처분별주사0.01,0.03,0.044 g/mL신벌타정/갑기섬유소응효50μL,대조조우인공근분차결손처주사갑기섬유소응효50μL,1차/주,련속8주;공백대조조불작임하처리. 결과여결론:여대조조화공백대조조비교,저、중、고농도신벌타정/갑기섬유소응효조근분차구아조골고도명현수복(P<0.001),신생아조골궤호충만근분차구,가견골소량성망상결구급성숙적합불씨계통,기중저농도신벌타정/갑기섬유소응효조신생골성숙도교중、고농도신벌타정/갑기섬유소응효조고,차염증세포침윤교소.대조조여공백대조조미견명현신생골,부견소량신생골.표명국부응용신벌타정/갑기섬유소응효가자격근분차구아조골결손후적골재생,괄의제량시0.01 g/mL.
BACKGROUND:Studies have shown that statins can stimulate the bone regeneration. @@@@ONJECTIVE:To investigate the effects of simvastatin/methylcel ulose gel on bone regeneration after grade Ⅱfurcation of alveolar defects in miniature pigs. @@@@METHODS:Grade Ⅱ furcation of alveolar defects model were produced in 32 teeth (the third and fourth premolars) of miniature pigs. The 32 experimental teeth were divided into five groups:the low-, middle-and high-dose simvastatin/methylcel ulose gel groups were injected with 0.01, 0.03 and 0.044 g/mL simvastatin/methylcel ulose gel 50μL into the furcation sites;the control group was injected with 50μL simvastatin/methylcel ulose gel into the furcation sites once a week and lasted for 8 weeks;the blank control group had no treatment. @@@@RESULTS AND CONCLUSION:Compared with the control group and blank control group, the height of the alveolar bone in the furcation sites of low-, middle-and high-dose simvastatin/methylcel ulose gel groups were increased (P<0.001), and the furcation sites were fil ed with the new alveolar bone, the trabecular was in the network structure and the mature Harvard’s system. The maturity of the new alveolar bone in the low-dose simvastatin/methylcel ulose gel group was higher than that in the middle-and high-dose simvastatin/methylcel ulose gel groups with less inflammatory cel infiltration. Little new alveolar bone could be seen in the control group and blank control group. Local application of simvastatin/methylcel ulose gel can stimulate the regeneration of alveolar bone in furcation defect sites and the best dose of simvastatin/methylcel ulose gel is 0.01 g/mL.