CAJ | 학술논문

背景:实验证明聚酸酐-吡柔比星植入剂可长时间保持体内血药浓度相对恒定. 目的:观察聚酸酐-吡柔比星植入剂在膀胱肿瘤大鼠体内的抑瘤作用. 方法:通过N-正丁基-N-(4-羟基-丁基)亚硝胺喂饲构建SD大鼠膀胱癌模型,随机分为实验组与对照组,分别将聚酸酐-吡柔比星植入剂和相同剂量吡柔比星植入模型动物体内膀胱黏膜下,用高效液相色谱仪检测动物体内吡柔比星血药浓度及肿瘤大小变化. 结果与结论:实验组吡柔比星在释放过程中无突释效应,基本满足长效局部植入剂应用于膀胱癌治疗的基本要求,可持续释放80 d以上;对照组吡柔比星浓度开始明显升高,5 d后迅速降低,不能维持有效治疗浓度1.0-3.0 mg/L.植入后30 d,实验组肿瘤体积较植入前明显缩小,抑瘤率高于对照组(P<0.05),且实验组动物平均存活期长于对照组(P<0.05).
배경:실험증명취산항-필유비성식입제가장시간보지체내혈약농도상대항정. 목적:관찰취산항-필유비성식입제재방광종류대서체내적억류작용. 방법:통과N-정정기-N-(4-간기-정기)아초알위사구건SD대서방광암모형,수궤분위실험조여대조조,분별장취산항-필유비성식입제화상동제량필유비성식입모형동물체내방광점막하,용고효액상색보의검측동물체내필유비성혈약농도급종류대소변화. 결과여결론:실험조필유비성재석방과정중무돌석효응,기본만족장효국부식입제응용우방광암치료적기본요구,가지속석방80 d이상;대조조필유비성농도개시명현승고,5 d후신속강저,불능유지유효치료농도1.0-3.0 mg/L.식입후30 d,실험조종류체적교식입전명현축소,억류솔고우대조조(P<0.05),차실험조동물평균존활기장우대조조(P<0.05).
BACKGROUND:Experimental studies have shown that polyanhydride-pirarubicin implants can maintain relatively constant blood concentration for a long term. @@@@OBJECTIVE:To observe the in vivo antitumor effect of polyanhydride-pirarubicin implants in the bladder tumors in rats. @@@@METHODS:Sprague-Dawley rat bladder cancer models were built by the N-butyl-N-(4-hydroxy-butyl) nitrosamine feeding, and then were randomly divided into experimental and control groups. Polyanhydride-pirarubicin implants and the same dose of pirarubicin implants were implanted into the bladder submucosathe of rat models. High performance liquid chromatography detection was done for monitoring plasma concentration and changes in tumor size. @@@@RESULTS AND CONCLUSION:In the experimental group, there was no burst effect during the release of pirarubicin, basical y meeting the requirements of long-acting local implants used in the treatment of bladder cancer (sustained release of over 80 days). In the control group, pirarubicin concentration significantly increased firstly, then decreased rapidly after 5 days and it was unable to maintain the effective therapeutic concentrations (1.0-3.0 mg/L). Thirty days after implantation, the tumor size in the experimental group was significantly reduced, and the inhibition rate in the experimental group was higher than that in the control group (P<0.05). Rats in the experimental group had a longer average survival period than those in the control group (P<0.05).