CAJ | 학술논문

背景:由于纳米羟基磷灰石粒子易团聚,由其制得的复合材料力学性能始终达不到皮质骨的水平. 目的:通过新方法制备稳定的羟基磷灰石胶体,克服粒子团聚. 方法:在0.05 mol/L硝酸钙溶液38 mL中分别加入等体积的2-氨乙基磷酸,3-膦酸基丙酸,L-O-磷酸丝氨酸溶液.将7.5mL的0.15 mol/L磷酸三铵溶液分别加入到上述每种混合液中,在40,80℃各老化4 h.所得的有机磷改性羟基磷灰石通过离心和水洗提纯,冷冻干燥得粉体. 结果与结论:红外光谱和X射线衍射证实改性后的物质仍为羟基磷灰石,表面改性剂接枝量很少.Zeta 电位分析表明3-膦酸基丙酸-羟基磷灰石、L-O-磷酸丝氨酸-羟基磷灰石可带上负电荷,2-氨乙基磷酸-羟基磷灰石可带上正电荷.3-膦酸基丙酸-羟基磷灰石、L-O-磷酸丝氨酸-羟基磷灰石的粉体在水中超声4 h,得到碱性条件下稳定性较好(3 d)的淡蓝色胶体;2-氨乙基磷酸-羟基磷灰石再分散胶体在酸性条件下的稳定性略好于中性条件,和碱性条件下相当,但都不理想(<3 h).表明提高羟基磷灰石胶体的稳定性还需探索新的方法.
배경:유우납미간기린회석입자역단취,유기제득적복합재료역학성능시종체불도피질골적수평. 목적:통과신방법제비은정적간기린회석효체,극복입자단취. 방법:재0.05 mol/L초산개용액38 mL중분별가입등체적적2-안을기린산,3-련산기병산,L-O-린산사안산용액.장7.5mL적0.15 mol/L린산삼안용액분별가입도상술매충혼합액중,재40,80℃각노화4 h.소득적유궤린개성간기린회석통과리심화수세제순,냉동간조득분체. 결과여결론:홍외광보화X사선연사증실개성후적물질잉위간기린회석,표면개성제접지량흔소.Zeta 전위분석표명3-련산기병산-간기린회석、L-O-린산사안산-간기린회석가대상부전하,2-안을기린산-간기린회석가대상정전하.3-련산기병산-간기린회석、L-O-린산사안산-간기린회석적분체재수중초성4 h,득도감성조건하은정성교호(3 d)적담람색효체;2-안을기린산-간기린회석재분산효체재산성조건하적은정성략호우중성조건,화감성조건하상당,단도불이상(<3 h).표명제고간기린회석효체적은정성환수탐색신적방법.
BACKGROUND:Nano-hydroxyapatite particles agglomerate so easily that their polymer-based nanocomposites are inferior to cortical bones in mechanical properties. @@@@OBJECTIVE:To prepare stable hydroxyapatite (HA) col oid by new methods. @@@@METHODS:38 mL calcium nitrate solution (0.05 mol/L) was mixed with an isovolumetric solution of 2-aminoethyl dihydrogen phosphate (ADP), 3-phosphonopropionic acid (CEPA) and L-O-phosphoserine (LOP), respectively. Thereafter, 7.5 mL triammonium phosphate solution (0.15 mol/L) was dropped into each of the mixtures fol owed by aging at 40 ℃ and 80 ℃ for 4 hours, respectively. The modified HAs (ADP-HA, CEPA-HA, LOP-HA) were purified through centrifugation and water washing, fol owed by freeze drying. @@@@RESULTS AND CONCLUSION:The as-synthesized products were stil HA as proved by Fourier transform infrared spectroscopy and X-ray diffraction analyses, with some modifiers on surface. Zeta potentials showed that the CEPA-HA and LOP-HA were negatively charged while the ADP-HA was positively charged. The CEPA-HA and LOP-HA were re-suspended in water through 4-hour ultrasonication, forming light blue col oids with short-term (3 days) stability at pH 11. The ADP-HA suspension possessed slightly higher stability in acidic solution than that in neutral one, similar to the case in alkaline solution. But its stability in al cases (<3 hours) was far from an ideal one. Creative methods should be under way to improve HA hydrocol oids’ stability.