CAJ | 학술논문

背景:纳米羟基磷灰石是一种具有代表性的生物活性材料,是现在组织工程领域研究的一个热点. 目的:综述纳米羟基磷灰石在骨科领域的临床应用进展,并探讨其作用机制. 方法:查阅2001年1月至2011年12月 CNKI 数据库和PubMed数据库有关纳米羟基磷灰石对成骨细胞、破骨细胞的影响及再血管化的研究,并总结其在骨科的临床应用进展. 结果与结论:纳米羟基磷灰石能够提高成骨细胞的增殖活性及功能代谢,诱发新骨形成;而破骨细胞能够吸收、降解羟基磷灰石,同时,纳米羟基磷灰石调节破骨细胞的代谢过程,共同参与了骨代谢.另外,纳米羟基磷灰石植入体内后能够再血管化,进而有利于骨修复和重建.基于纳米羟基磷灰石及其复合材料的优越性,是一种较为理想的骨缺损修复材料,已初步应用于临床,并取得了令人鼓舞的效果,但仍有许多问题有待于进一步研究解决.
배경:납미간기린회석시일충구유대표성적생물활성재료,시현재조직공정영역연구적일개열점. 목적:종술납미간기린회석재골과영역적림상응용진전,병탐토기작용궤제. 방법:사열2001년1월지2011년12월 CNKI 수거고화PubMed수거고유관납미간기린회석대성골세포、파골세포적영향급재혈관화적연구,병총결기재골과적림상응용진전. 결과여결론:납미간기린회석능구제고성골세포적증식활성급공능대사,유발신골형성;이파골세포능구흡수、강해간기린회석,동시,납미간기린회석조절파골세포적대사과정,공동삼여료골대사.령외,납미간기린회석식입체내후능구재혈관화,진이유리우골수복화중건.기우납미간기린회석급기복합재료적우월성,시일충교위이상적골결손수복재료,이초보응용우림상,병취득료령인고무적효과,단잉유허다문제유대우진일보연구해결.
BACKGROUND:Nano-hydroxyapatite is a representative bioactive material, which has been the focus of tissue engineering research. @@@@OBJECTIVE:To review the orthopedic application and mechanism of nano-hydroxyapatite. @@@@METHODS:CNKI and PubMed databases (2001-01/2011-12) were retrieved for articles related to the effect of nano-hydroxyapatite on osteoblasts, osteoclasts, and revascularization to summarize the clinical progress of nano-hydroxyapatite in orthopedics. @@@@RESULTS AND CONCLUSION:Nano-hydroxyapatite can enhance the proliferation activity and functional metabolism of osteoblasts, and induce new bone formation. However, osteoclasts can absorb and degrade hydroxyapatite, and meanwhile, nano-hydroxyapatite can regulate osteoclast's metabolic processes and they influence each other in the bone metabolism. In addition, after implantation, nano-hydroxyapatite can be revascularized quickly and completely that is conducive to bone repairing and rebuilding. In view of the superiorities of nano-hydroxyapatite and its composite materials, nano-hydroxyapatite is an ideal material for repairing bone defects and has been preliminarily used in clinic. But there are stil many problems to be solved in the future.