CAJ | 학술논문

背景:骨性关节炎是生物学、生物化学、分子生物学、酶的反馈作用等复杂的多种机制相互作用的结果,其病理过程与细胞因子密切相关. 目的:总结细胞因子在骨性关节炎发生、发展过程中作用的研究现状. 方法:由第一作者用计算机检索万方数据库(2000至2012年)和PubMed 数据库(2000至2012年)收录的细胞因子与骨性关节炎相关论文报告. 结果与结论:共纳入细胞因子与骨性关节炎相关文献69篇.细胞因子在骨性关节炎发生、发展过程中起重要作用,能促进骨性关节炎软骨降解、滑膜炎症及软骨下骨的吸收,部分细胞因子也有抑制骨性关节炎病变发展的作用.与分解代谢有关的细胞因子主要有基质金属蛋白酶;与合成代谢有关的细胞因子主要有转化生长因子,骨形态发生蛋白,胰岛素样生长因子,成纤维细胞生长因子和血管内皮细胞生长因子;在关节组织中发现的影响细胞功能的炎性因子包括白细胞介素、趋化因子和肿瘤坏死因子等.但细胞因子在骨性关节炎发生、发展过程中作用机制及临床应用需要进一步研究.
배경:골성관절염시생물학、생물화학、분자생물학、매적반궤작용등복잡적다충궤제상호작용적결과,기병리과정여세포인자밀절상관. 목적:총결세포인자재골성관절염발생、발전과정중작용적연구현상. 방법:유제일작자용계산궤검색만방수거고(2000지2012년)화PubMed 수거고(2000지2012년)수록적세포인자여골성관절염상관논문보고. 결과여결론:공납입세포인자여골성관절염상관문헌69편.세포인자재골성관절염발생、발전과정중기중요작용,능촉진골성관절염연골강해、활막염증급연골하골적흡수,부분세포인자야유억제골성관절염병변발전적작용.여분해대사유관적세포인자주요유기질금속단백매;여합성대사유관적세포인자주요유전화생장인자,골형태발생단백,이도소양생장인자,성섬유세포생장인자화혈관내피세포생장인자;재관절조직중발현적영향세포공능적염성인자포괄백세포개소、추화인자화종류배사인자등.단세포인자재골성관절염발생、발전과정중작용궤제급림상응용수요진일보연구.
BACKGROUND:Osteoarthritis is a kind of normal disease, results from a complex system of interacting mechanical, biological, biochemical, molecular and enzymatic feedback loops. Cytokines are closely related to the pathological process of osteoarthritis. @@@@OBJECTIVE:To summarize the research progress of cytokines in the occurring and development of osteoarthritis. @@@@METHODS:An online search of Wanfang database and PubMed database was performed by the first author for articles published between 2000 and 2012 that related to cytokines and osteoarthritis. @@@@RESULTS AND CONCLUSION:A total of 69 articles on the application of cytokines in osteoarthritis were included. Cytokines play an important role in the occurring and development process of osteoarthritis;cytokines can promote the degradation of osteoarthritic cartilage, synovitis and resorption of subchondral bone. Some cytokines also have an inhibitory effect in the development of osteoarthritis. Matrix metal oproteinase is related to catabolism;transforming growth factor, bone morphogenic protein, insulin-like growth factor, fibroblast growth factor and vascular endothelial growth factor are related to anabolism. Inflammatory factors which affect the function of joint cel s include interleukin, chemokine and tumor necrosis factor. But the mechanisms of cytokines in the occurring and the development of osteoarthritis and clinical application of cytokines need further study.