CAJ | 학술논문

目的:探讨抗精神疾病药加用氟西汀治疗精神分裂症阴性症状的临床疗效.方法:对58例以阴性症状为主的慢性精神分裂症患者,在原用抗精神疾病药治疗的基础上,随机抽取29例给予抗精神疾病药加用氟西汀作为治疗组;其余作为对照组;疗程12周.疗效和不良反应评定采用阳性与阴性症状量表(PANSS)和治疗中出现的药物不良反应评定量表(TESS)评定,与治疗前及治疗4、8、12周各评定1次.结果:治疗8周起合用组 PANSS 总分及阴性因子分均比治疗前显著降低,且合用组的体重增加明显低于对照组.结论:以阴性症状为主的慢性精神分裂症患者,使用抗精神疾病药同时联用氟西汀可改善阴性症状,并对患者的体重增长有抑制作用.
목적:탐토항정신질병약가용불서정치료정신분렬증음성증상적림상료효.방법:대58례이음성증상위주적만성정신분렬증환자,재원용항정신질병약치료적기출상,수궤추취29례급여항정신질병약가용불서정작위치료조;기여작위대조조;료정12주.료효화불량반응평정채용양성여음성증상량표(PANSS)화치료중출현적약물불량반응평정량표(TESS)평정,여치료전급치료4、8、12주각평정1차.결과:치료8주기합용조 PANSS 총분급음성인자분균비치료전현저강저,차합용조적체중증가명현저우대조조.결론:이음성증상위주적만성정신분렬증환자,사용항정신질병약동시련용불서정가개선음성증상,병대환자적체중증장유억제작용.
Objective To explore the efficacy of antipsychotics combined with hydrochloride in the treatment of chronic schizophrenia with negative symptoms.Methods Fifty-eight cases of chronic schizophrenia mainly with negative symptoms were randomly divided into combined groups(treated with antipsychotics and hydrochloride) and control group(treated with placebo).Twenty-nine cases respectively.The course of treatment was twelve weeks,The efficiency and side effects were evaluated by positive and negative symptoms scale(PANSS) treatment emergent symptoms scale(TESS) before and after treatments for 4,8,12 weeks.Results After 8 weeks treatments,the total scores and negative symptoms scale