CAJ | 학술논문

目的探讨鞘内神经干细胞移植治疗急性脑出血的近期疗效与安全性.方法于脑出血发病第7天经腰椎穿刺蛛网膜下腔移植神经干细胞,4.0×108个/次,每周2次,共4次.分别于入院当天及发病第7天、第14天、第21天和第28天进行 NIHSS 评分与脑 CT 扫描检查,确定神经功能和血肿周围病灶体积的变化.结果自发病第14天始,患者 NIHSS 评分和血肿周围病灶体积都在明显减少,治疗前后组内比较及治疗前后组间之间的比较,差异都十分显著,P均<0.05.治疗过程中除少数病人有一过性发烧、寒战外,无其他不良反应.结论鞘内神经干细胞移植治疗脑出血安全有效.
목적탐토초내신경간세포이식치료급성뇌출혈적근기료효여안전성.방법우뇌출혈발병제7천경요추천자주망막하강이식신경간세포,4.0×108개/차,매주2차,공4차.분별우입원당천급발병제7천、제14천、제21천화제28천진행 NIHSS 평분여뇌 CT 소묘검사,학정신경공능화혈종주위병조체적적변화.결과자발병제14천시,환자 NIHSS 평분화혈종주위병조체적도재명현감소,치료전후조내비교급치료전후조간지간적비교,차이도십분현저,P균<0.05.치료과정중제소수병인유일과성발소、한전외,무기타불량반응.결론초내신경간세포이식치료뇌출혈안전유효.
Objective To explore the short term efficacy and safety of neural stem cels intrathecal transplantation for the treatment of cerebral hemorrhage. Methods 4.0×108 neural stem cels per time were transplanted into subarachnoid space by lumbar puncture seven days after cerebral hemorrhage, twice per week, a total of four times. NIHSS scores and brain CT scan were conducted to assess patients’ neural functions and the volume of perihematom lesions at the first, seventh, fourteenth, twenty-first and twenty-eighth day. Result The NIHSS scores and the volume of perihematom lesions were significantly reduce since the fourteenth day. The differences were very significant by the intra-group and between-group comparison before and after treatment (P<0.05). There were no adverse reactions except transient fever and shiver in a few patients. Conclusion The neural stem cels intrathecal transplantation for the treatment of cerebral hemorrhage was safe and effective.