CAJ | 학술논문

目的观察氯吡格雷在急性脑梗死治疗中的临床疗效及安全性.方法将我科室2011年1月至2012年6月收治的急性脑梗死病人50例随机分为两组,在常规治疗基础上,观察组为加用氯吡格雷,对照组加用肠溶阿司匹林,观察治疗2周后的两组临床疗效,神经功能缺损评分及不良反应的发生.结果治疗2周后,两组神经功能缺损评分 NIHSS 评分均明显降低(p <0.05),观察组评分降低程度明显优于对照组,且差异有显著性(p <0.05).观察组的总有效率明显高于对照组(p <0.05),治疗过程中观察组无明显不良反应,对照组发生消化道反应3例,均无明显出血等严重不良反应发生.结论氯吡格雷治疗急性脑梗死疗效确切,且安全性可靠.
목적관찰록필격뢰재급성뇌경사치료중적림상료효급안전성.방법장아과실2011년1월지2012년6월수치적급성뇌경사병인50례수궤분위량조,재상규치료기출상,관찰조위가용록필격뢰,대조조가용장용아사필림,관찰치료2주후적량조림상료효,신경공능결손평분급불량반응적발생.결과치료2주후,량조신경공능결손평분 NIHSS 평분균명현강저(p <0.05),관찰조평분강저정도명현우우대조조,차차이유현저성(p <0.05).관찰조적총유효솔명현고우대조조(p <0.05),치료과정중관찰조무명현불량반응,대조조발생소화도반응3례,균무명현출혈등엄중불량반응발생.결론록필격뢰치료급성뇌경사료효학절,차안전성가고.
Objective: to observe the clinical curative effect and security of clopidogrel in the acute cerebral infarction. Methods: 50 cases of patients with acute cerebral infarction between January 2011 and June 2012 randomly divided into observation group and control group, the observation group (25 cases) received clopidogrel combined with conventional treatment;The control group (25 cases) received enteric aspirin combined with conventional treatment. The nerve function defect score scores ( NIHSS) and the adverse events are observed 2 weeks later .The result: NIHSS of the observation group were lower than that of the control group significantly, (p< 0.01). The observation group total effective rate was obviously higher than that of the control group (p< 0.01). No obvious adverse reaction occurred in patients of the observation group during the process of treatment, while gastrointestinal reaction occurred in 3 patients of the control group. Both groups have no obvious bleeding and other serious adverse reaction. Conclusion: the curative effect of clopidogrel in acute cerebral infarction is definite, safety and reliable.