医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2012年
33期
128
,共1页
持续皮下胰岛素注射%肥胖%糖尿病, 2 型%β细胞功能
持續皮下胰島素註射%肥胖%糖尿病, 2 型%β細胞功能
지속피하이도소주사%비반%당뇨병, 2 형%β세포공능
Continuous subcutaneous insulin infusion%Obesity%type2 diabetes melitus%β- cel function
目的观察合并肥胖的2型糖尿病(T2DM)患者短期持续胰岛素输注(CSI)强化治疗的效果,并比较肥胖和正常体重的T2DM患者疗效的差别.方法对43名合并肥胖的T2DM 患者(OB组)和41名体重正常的T2DM 患者(NW组)用CSI 胰岛素强化治疗14d.治疗前和治疗第15天分别进行OGTT(OGTT 组),比较两组治疗前后体质量指数(BMI)、血糖(PG)、稳态模型评估法胰岛素抵抗指数(HOMA-IR)、细胞功能指数(HOMA-β)、胰岛素分泌指数等指标的变化.结果(1)治疗后两组均HOMA- IR 降低, HOMA-β、△I30/△G30、△I120/△G120以及AUCins明显升高(P<0.01或P<0.05);(2)OB组反映胰岛B细胞功能的指标改善比NW组更明显(与NW组相比,P<0.05),BMI的增加幅度与NW组相比无显著差异(P>0.05).结论短期胰岛素强化治可明显改善合并肥胖的2型糖尿病患者的B 细胞功能,且没有过多地增加体重.
目的觀察閤併肥胖的2型糖尿病(T2DM)患者短期持續胰島素輸註(CSI)彊化治療的效果,併比較肥胖和正常體重的T2DM患者療效的差彆.方法對43名閤併肥胖的T2DM 患者(OB組)和41名體重正常的T2DM 患者(NW組)用CSI 胰島素彊化治療14d.治療前和治療第15天分彆進行OGTT(OGTT 組),比較兩組治療前後體質量指數(BMI)、血糖(PG)、穩態模型評估法胰島素牴抗指數(HOMA-IR)、細胞功能指數(HOMA-β)、胰島素分泌指數等指標的變化.結果(1)治療後兩組均HOMA- IR 降低, HOMA-β、△I30/△G30、△I120/△G120以及AUCins明顯升高(P<0.01或P<0.05);(2)OB組反映胰島B細胞功能的指標改善比NW組更明顯(與NW組相比,P<0.05),BMI的增加幅度與NW組相比無顯著差異(P>0.05).結論短期胰島素彊化治可明顯改善閤併肥胖的2型糖尿病患者的B 細胞功能,且沒有過多地增加體重.
목적관찰합병비반적2형당뇨병(T2DM)환자단기지속이도소수주(CSI)강화치료적효과,병비교비반화정상체중적T2DM환자료효적차별.방법대43명합병비반적T2DM 환자(OB조)화41명체중정상적T2DM 환자(NW조)용CSI 이도소강화치료14d.치료전화치료제15천분별진행OGTT(OGTT 조),비교량조치료전후체질량지수(BMI)、혈당(PG)、은태모형평고법이도소저항지수(HOMA-IR)、세포공능지수(HOMA-β)、이도소분비지수등지표적변화.결과(1)치료후량조균HOMA- IR 강저, HOMA-β、△I30/△G30、△I120/△G120이급AUCins명현승고(P<0.01혹P<0.05);(2)OB조반영이도B세포공능적지표개선비NW조경명현(여NW조상비,P<0.05),BMI적증가폭도여NW조상비무현저차이(P>0.05).결론단기이도소강화치가명현개선합병비반적2형당뇨병환자적B 세포공능,차몰유과다지증가체중.
Objective To explore the effect o f short- term insulin intensive treatment in type 2 diabetes( T2DM) with obesity and compare the different therapeutic effects between the obesity group and nomal weigh group in T2DM. Methods 14 days short- term continuous subcutaneous insulin infusion ( CSI) was applied on insulin intensively treatment in 43 T2DM with obesity(OB group) and 42 T2DM with nomal weigh (NW group),Before and after 14 days CSI tr eatments, OGTT were performed. The changes o f t he values of body mass index(BMI), plasma g lucose( PG), HOMA- IR, H OMA-B , indexes of insulin secretion were compared respectively in two groups.Results 1.The leveves of HOMA-β,△I30/△G30、△I120/△G120 and AUCins were increased,HOMA-IR were decreased significantly after CSI therapy in both groups(P<0.01或P<0.05). 2.The indicators of b-cel function improved much more in OB group than in NW group (P<0.05), but there is no different statisticaly between the two groups on weigh gain.Conclusions Short-term intensive insulin therapy improvsβ- cel function without excessive weigh gain in T2DM with obesity.
