CAJ | 학술논문

目的研究注射用伏立康唑对小鼠的急性毒性作用,为临床安全用药提供参考.方法将注射用伏立康唑配制成适当浓度,观察小鼠静脉注射的急性毒性.结果注射用伏立康唑小鼠急性毒性试验设定剂量分别为:274mg/kg、247mg/kg、222mg/kg、200mg/kg、180mg/kg、162mg/kg和对照组.274mg/kg组死亡率为90%;247mg/kg组死亡率为70%;222mg/kg组死亡率为40%;200mg/kg组死亡率为30%;180mg/kg组死亡率为20%.162mg/kg和对照组无动物死亡.结论注射用伏立康唑小鼠静脉给药半数致死量(LD50)为223.07mg/kg,95%可信区间为208.18-239.03.
목적연구주사용복립강서대소서적급성독성작용,위림상안전용약제공삼고.방법장주사용복립강서배제성괄당농도,관찰소서정맥주사적급성독성.결과주사용복립강서소서급성독성시험설정제량분별위:274mg/kg、247mg/kg、222mg/kg、200mg/kg、180mg/kg、162mg/kg화대조조.274mg/kg조사망솔위90%;247mg/kg조사망솔위70%;222mg/kg조사망솔위40%;200mg/kg조사망솔위30%;180mg/kg조사망솔위20%.162mg/kg화대조조무동물사망.결론주사용복립강서소서정맥급약반수치사량(LD50)위223.07mg/kg,95%가신구간위208.18-239.03.
Objective To evaluate the acute toxicity of voriconazole for injection. Methods Voriconazole for injection was dissolved in 5% glucose injection. Results The mouse were treated with 274mg/kg, 247mg/kg, 222mg/kg, 200mg/kg、180mg/kg or162mg/kg of the compound once, while the control group received only 5% glucose injection. The death rate in 274mg/kg group were 90%, 70% in 247mg/kg group, 40% in 222.0 mg/kg group, 30% in 200mg/kg group and 20% in 180 mg/kg group. There was no death mice in 162mg/kg group and the control group. Conclusion The dose of LD50 of voriconazole for injection in mice was 223.07mg/kg, and a 95% confidence range of its LD50 was 208.18-239.03.