CAJ | 학술논문

目的探讨血清 Obestatin、Ghrelin 与 GDM 发病的关系及其与胰岛素抵抗之间的关系.方法回顾性分析2011年6-12月在粤北人民医院妇产科孕妇的临床资料.结果(1)除空腹血清 Obestatin、Ghrelin 水平外,GDM 患者其他数据均高于正常妊娠者(P<0.05).(2) GDM 患者空腹血清 Obestatin、Ghrelin 水平皆与BMI、FINS、HOMA-IR 呈负相关,Ghrelin/Obestatin 比值与各因素均无相关性(P>0.05).结论 GDM 患者血清 Obestatin、Ghrelin 水平与胰岛素抵抗、体重指数关系密切;Ghrelin/Obestatin 比值变化与代谢紊乱有关,可能参与了肥胖、IR 的发生,低水平的 Obestatin、Ghrelin 可能具有防止肥胖和妊娠期糖尿病继续进展的作用.
목적탐토혈청 Obestatin、Ghrelin 여 GDM 발병적관계급기여이도소저항지간적관계.방법회고성분석2011년6-12월재월북인민의원부산과잉부적림상자료.결과(1)제공복혈청 Obestatin、Ghrelin 수평외,GDM 환자기타수거균고우정상임신자(P<0.05).(2) GDM 환자공복혈청 Obestatin、Ghrelin 수평개여BMI、FINS、HOMA-IR 정부상관,Ghrelin/Obestatin 비치여각인소균무상관성(P>0.05).결론 GDM 환자혈청 Obestatin、Ghrelin 수평여이도소저항、체중지수관계밀절;Ghrelin/Obestatin 비치변화여대사문란유관,가능삼여료비반、IR 적발생,저수평적 Obestatin、Ghrelin 가능구유방지비반화임신기당뇨병계속진전적작용.
Objective To study relationship between serum obestatin, ghrelin levels and gestational diabetes melitus insulin resistance. Methods Retrospective analysis the clinical informations of patients between June 2011 to December 2011 in Yuebei People’s hospital. Results (1) Except the levels of fasting serum obestatin and ghrelin of gestational diabetes patients were higher than those of normal controls. (2)The fasting serum obestatin, ghrelin levels of the gestational diabetes patients were negatively correlated with BMI,FINS and HOMA-IR, ghrelin/obestatin ratio has no statistical correlations with other factors. Conclusions Serum Obestatin, Ghrelin levels have close relationships with insulin resistance and body mass index in gestational diabetes patients.The changes of Obestatin. Ghrelin, Ghrelin/Obestatin ratio are correlated with metabolic disorders, that may play an important role in the development of obesity and insulin resistance.The decrease of circulating Obestatin and Ghrelin may prevent the continued development of obesity and gestational diabetes melitus.