CAJ | 학술논문

目的了解我院院内感染铜绿假单胞菌的临床分布和耐药情况,为临床预防和治疗铜绿假单胞菌院内感染提供依据.方法采用回顾性分析方法分析2009-2012年间院内住院患者分离铜绿假单胞菌病区分布、药敏结果、耐药性变化和耐药组合情况.结果4年间铜绿假单胞菌分离率较高的科室分别为神经外科、中心重症监护室和神经内科.痰标本检出铜绿假单胞菌最多,占74.4%.药敏结果显示哌拉西林,哌拉西林/他唑巴坦,庆大霉素,头孢吡肟(FEP)等20种抗菌药物耐药率呈下降的趋势.结论医院内获得铜绿假单胞菌感染以下呼吸道感染为主,且耐药性明显高于其他部位分离菌株.铜绿假单胞菌耐药机制复杂,临床应根据其分布特点和药敏结果合理用药.
목적료해아원원내감염동록가단포균적림상분포화내약정황,위림상예방화치료동록가단포균원내감염제공의거.방법채용회고성분석방법분석2009-2012년간원내주원환자분리동록가단포균병구분포、약민결과、내약성변화화내약조합정황.결과4년간동록가단포균분리솔교고적과실분별위신경외과、중심중증감호실화신경내과.담표본검출동록가단포균최다,점74.4%.약민결과현시고랍서림,고랍서림/타서파탄,경대매소,두포필우(FEP)등20충항균약물내약솔정하강적추세.결론의원내획득동록가단포균감염이하호흡도감염위주,차내약성명현고우기타부위분리균주.동록가단포균내약궤제복잡,림상응근거기분포특점화약민결과합리용약.
Objective To investigate antimicrobial resistance of clinical isolates of our hospital ,to offer information for preventing and curing Pseudomonas aeruginosa. Methods the retrospective analytical method test was employed to study the antimicrobial resistance. Results the top three the division of isolating rate of Pseudomonas aeruginosa is neurosurgery,ICU and neurology department. The strains were separated from sputum accounted for 74.4% ,which is the most. There is an obvious descending tendency of antimicrobial resistance of Pseudomonas aeruginosa for Amikacin, Aztreonam, Aztreonam, Piperacilin, Piperacilin/ Tazobactam, Gentamycin, Gentamycin/ Clavulanic Acid, Cefepime, Ceftazidime, Tobramycin, Imipenem, Levofloxacin, Cefotaxime, Ceftriaxone. Oppositey, there is not for Cefotaxime/ Clavulanic Acid, Ampicilin, Ampicilin/ Ampicilin, trimethoprim-sulfamethoxazole, Cefoxitin, Cephazolin. Conclusion the primary infection in Hospitals is lower respiratory tract infection, which is supper than other position infection. The antimicrobial resistance mechanism of Pseudomonas aeruginosa is multiplicity. So, we should take the rational use of drug ,according to the antimicrobial resistance of clinical isolates of our hospital.