CAJ | 학술논문

目的比较酒石酸布托啡诺与地佐辛用于腹腔镜胆囊切除术后镇痛的有效性及安全性.方法回顾性分析上海市亭林医院2011年1月至2011年12月收治的腹腔镜胆囊切除术患者的病例资料,比较应用两种不同术后镇痛方法患者术后的疼痛程度、舒适度、镇静度及不良反应差异.结果总病例数383例,其中酒石酸布托啡诺镇痛组(A组)92例,地佐辛镇痛组(B组)116例,其余175例术后未使用镇痛药(C组).三组间一般情况的差异无统计学意义.A、B两组患者术后各时间点镇痛程度评分(VAS)均低于C组(P <0.05).与A组相比,B组患者VAS评分在术后2小时内高于A组,4小时后则低于A组(P<0.05).A、B两组患者术后各时间点镇静程度评分(BCS)及舒适度评分(Ramsay)均低于C组(P <0.05),A、B两组比较差异无统计学意义(P >0.05).A、B两者不良反应差异无统计学意义(P >0.05).结论酒石酸布托啡诺与地佐辛用于腹腔镜胆囊切除术后镇痛安全、有效.酒石酸布托啡诺镇痛起效快,地佐辛镇痛维持时间长.
목적비교주석산포탁배낙여지좌신용우복강경담낭절제술후진통적유효성급안전성.방법회고성분석상해시정림의원2011년1월지2011년12월수치적복강경담낭절제술환자적병례자료,비교응용량충불동술후진통방법환자술후적동통정도、서괄도、진정도급불량반응차이.결과총병례수383례,기중주석산포탁배낙진통조(A조)92례,지좌신진통조(B조)116례,기여175례술후미사용진통약(C조).삼조간일반정황적차이무통계학의의.A、B량조환자술후각시간점진통정도평분(VAS)균저우C조(P <0.05).여A조상비,B조환자VAS평분재술후2소시내고우A조,4소시후칙저우A조(P<0.05).A、B량조환자술후각시간점진정정도평분(BCS)급서괄도평분(Ramsay)균저우C조(P <0.05),A、B량조비교차이무통계학의의(P >0.05).A、B량자불량반응차이무통계학의의(P >0.05).결론주석산포탁배낙여지좌신용우복강경담낭절제술후진통안전、유효.주석산포탁배낙진통기효쾌,지좌신진통유지시간장.
Objective To compare the efficacy and safety of butorphanol bartrate and dezocine for postoperative analgesia in patients with laparoscopic cholecystectomy. Methods Clinical data about the patients who required laparoscopic cholecystectomy in Tinglin hospital during 2011 were analyzed retrospectively. The intensity of pain was evaluated using visual analogue scale (VAS), and comfort was assessed using bruggerman comfort scale (BCS), and sedation was evaluated using Ramsay. The side effects were recorded as wel. Results The total number of the patients was 383, including 92 patients using butorphanol bartrate (group A), 116 patients using dezocine (group B), and the other 175 patients using no analgesics. The three groups were comparable in regard to age, gender, weight, mean blood pressure and heart rate. VAS scores of both group A and B were significantly lower than group C. Compared with group A, VAS scores of group B were higher within 2 hours after operation, but were lower beyond 4 hours after operation. The BCS and Ramsay scores were comparable between group A and B, but both are higher than group C. No difference of adverse reactions were observed between group A and B. Conclusion Both butorphanol bartrate and dezocine were effective and safe for postoperative analgesia in patients with laparoscopic cholecystectomy. Butorphanol acted quicker, while dezocine last longer.