医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
4期
17-18
,共2页
产前诊断%羊水细胞%染色体%唐氏综合征
產前診斷%羊水細胞%染色體%唐氏綜閤徵
산전진단%양수세포%염색체%당씨종합정
Prenatal diagnosis%Amnioticfluid cel%Chromosome%Downsyndrome
目的研究羊水细胞染色体检查在临床产前诊断中的实用性和在染色体疾病诊断中的意义.方法对孕中期有穿刺指征的孕妇羊水细胞培养并进行染色体分析,检出异常核型及类型并统计.结果在成功培养的474例羊水中,检出异常核型22例,其中常染色体数目异常15例,性染色体数目异常1例,染色体结构异常6例,异常检出率为4.64%,染色体多态性核型22例.结论孕中期对染色体高危孕妇进行羊水染色体检查是产前诊断的重要手段.
目的研究羊水細胞染色體檢查在臨床產前診斷中的實用性和在染色體疾病診斷中的意義.方法對孕中期有穿刺指徵的孕婦羊水細胞培養併進行染色體分析,檢齣異常覈型及類型併統計.結果在成功培養的474例羊水中,檢齣異常覈型22例,其中常染色體數目異常15例,性染色體數目異常1例,染色體結構異常6例,異常檢齣率為4.64%,染色體多態性覈型22例.結論孕中期對染色體高危孕婦進行羊水染色體檢查是產前診斷的重要手段.
목적연구양수세포염색체검사재림상산전진단중적실용성화재염색체질병진단중적의의.방법대잉중기유천자지정적잉부양수세포배양병진행염색체분석,검출이상핵형급류형병통계.결과재성공배양적474례양수중,검출이상핵형22례,기중상염색체수목이상15례,성염색체수목이상1례,염색체결구이상6례,이상검출솔위4.64%,염색체다태성핵형22례.결론잉중기대염색체고위잉부진행양수염색체검사시산전진단적중요수단.
Objective Study amniotic fluid cel chromosome usefulness in clinical prenatal diagnosis and in the diagnosis of chromosomal disorders. Methods Puncture indications of second trimester amniotic fluid cel culture and chromosome analysis detected abnormal karyotype types and statistics. Results 474 cases were successfuly cultured amniotic fluid detection of abnormal karyotype 22 cases, autosomal abnormal number of 15 cases, the sex chromosome abnormalities, six cases of chromosome structural abnormalities, abnormal detection rate of 4.64%, chromosome polymorphismThe karyotype 22 cases. A conclusion Second trimester amniotic fluid chromosome chromosome-risk pregnant woman is an important means of prenatal diagnosis.
