CAJ | 학술논문

目的总结肝移植术后个体化免疫抑制剂的临床应用经验.方法回顾性分析2003年1月至2010年8月间在我院接受肝脏移植治疗的136例患者的临床资料.按免疫抑制剂的应用方案的不同,分为两个阶段.第一阶段:2003年1月至2007年6月为传统免疫抑制方案应用时期.第二阶段:2007年7月至2010年8月为个体化免疫抑制方案应用时期.结果第二阶段良性疾病及恶性疾病患者的生存率同第一阶段的生存率相比呈上升趋势.第二阶段各组排斥反应的发生率与第一阶段相比无差异,第二阶段各组感染的发生率、肾功能障碍的发生率低于第一阶段的发生率.结论针对不同病情患者,采用不同的免疫抑制方案,可提高患者的生存率,减少并发症的发生.
목적총결간이식술후개체화면역억제제적림상응용경험.방법회고성분석2003년1월지2010년8월간재아원접수간장이식치료적136례환자적림상자료.안면역억제제적응용방안적불동,분위량개계단.제일계단:2003년1월지2007년6월위전통면역억제방안응용시기.제이계단:2007년7월지2010년8월위개체화면역억제방안응용시기.결과제이계단량성질병급악성질병환자적생존솔동제일계단적생존솔상비정상승추세.제이계단각조배척반응적발생솔여제일계단상비무차이,제이계단각조감염적발생솔、신공능장애적발생솔저우제일계단적발생솔.결론침대불동병정환자,채용불동적면역억제방안,가제고환자적생존솔,감소병발증적발생.
Objective: To explore individual application of immunosuppressive agents after liver transplantation. Methods: The clinical datas of 136 undergoing liver transplantatio in our hospital from January 2003 to August 2010 were analyzed. The time were diveded into 2 stages according to application of immunosuppressive agents after liver transplantation. First stage is traditional application of immunosuppressive agents from January 2003 to June 2007;Second stage is individual application of immunosuppressive agents from July 2007 to August 2010. Results: survival rate of benign disease and malignant disease in second stage present upgrade tendency compared to first stage. Distinction of incidence rate of rejection was not found between individual group from each stage . Incidence rate of infection 、renal disfunction of second stage were less than which of first stage.Conclusion: individual application of immunosuppressive agents were applicated in individual patients can improve survival rate but decrease the complication of the liver transpalntation patients