CAJ | 학술논문

药物导致Q-T间期延长引发多形性室性心动过速或尖端扭转型室性心动过速(TdP),导致心室扑动或颤动比较罕见,但其为致命性心律失常,容易引起心源性猝死.本文介绍了容易引起Q-T间期延长的药物种类、作用机制与诱发Q-T间期延长的危险因素,以期加强对这些药物的认识,提供对此类药物的使用指导,促进合理安全用药.
약물도치Q-T간기연장인발다형성실성심동과속혹첨단뉴전형실성심동과속(TdP),도치심실복동혹전동비교한견,단기위치명성심률실상,용역인기심원성졸사.본문개소료용역인기Q-T간기연장적약물충류、작용궤제여유발Q-T간기연장적위험인소,이기가강대저사약물적인식,제공대차류약물적사용지도,촉진합리안전용약.
Some Drugs can induce Q-T interphase prolongation, even torsades de pointes(TdP). Though the side effect of drugs is no common, but is a fatal arrhythmia, and can cause sudden death. This paper introduces the drugs that can induce Q-T prolongation, their mechanism causing Q-T prolongation and some related risk factors, in order to strengthen the understanding of these drugs, provide guidance for the use of the drugs, and to promote rational and safe drug usage.