CAJ | 학술논문

目的:了解二甲双胍所致不良反应发生的情况并分析相关因素,为临床合理用药提供参考.方法:对二甲双胍所致的64例不良反应文献进行分类统计与分析.结果:男女比例基本为1:1,平均年龄为(59.7±14.4)岁,53.1%的病例不合理用药,56.3%的病例联合用药,临床类型以乳酸酸中毒为主(48.4%),其次为低血糖反应(25.0%),85.9%的病例治愈或好转,53.1%的病例合并有其他疾病.结论:二甲双胍可引起较为严重的不良反应,甚至可致死亡,使用时须慎重考虑年龄、用法用量及合并疾病等相关因素,做到合理用药,减少不良反应的发生.
목적:료해이갑쌍고소치불량반응발생적정황병분석상관인소,위림상합리용약제공삼고.방법:대이갑쌍고소치적64례불량반응문헌진행분류통계여분석.결과:남녀비례기본위1:1,평균년령위(59.7±14.4)세,53.1%적병례불합리용약,56.3%적병례연합용약,림상류형이유산산중독위주(48.4%),기차위저혈당반응(25.0%),85.9%적병례치유혹호전,53.1%적병례합병유기타질병.결론:이갑쌍고가인기교위엄중적불량반응,심지가치사망,사용시수신중고필년령、용법용량급합병질병등상관인소,주도합리용약,감소불량반응적발생.
Objective:To learn the adverse drug reactions caused by Metformin, relevant factors were analyzed in this review to provide a reference for clinical use of Metformin. Methods:64 cases of Metformin-induced adverse drug reactions were statistically analyzed. Results:The ratio of adverse drug reactions occurred on Male to Female was about 1:1. Average age is(59.7±14.4)years old. Among these adverse reactions, 53.1% of which are with unreasonable drug use, 56.3% are with combined use of drugs. Clinical symptoms mainly were lactic acidosis (48.4%), followed by hypoglycemia(25.0%. 85.9%of these cases were cured, whereas 53.1%were combined other diseases. Conclusion:Since Metformin can cause severe adverse drug reactions (even death), it must be carefully used by considering the age, usage, dosage and other factors to reduce the incidence of adverse drug reactions.