CAJ | 학술논문

目的:比较3种门冬胰岛素30联合用药方案对2型糖尿病患者的血糖波动的影响.方法:将2型糖尿病患者随机分为3组,A组:门冬胰岛素30注射液每日2次,联合二甲双胍片治疗;B组:门冬胰岛素30注射液每日3次,联合二甲双胍片治疗;C组:门冬胰岛素30注射液每日2次,联合二甲双胍片和阿卡波糖片治疗.收集疗效及安全性数据,进行统计学分析.结果:3种方案控制患者血糖效果理想,疗效和安全性相似,组间无显著性差异;但3组间SDBG有显著性差异,B组<C组<A组(F=6.02,P<0.01);A组晚餐前血糖值最高(7.14±1.06mmol/L,F=5.63,P<0.05).结论:B组方案血糖波动最小,A组方案晚餐前血糖控制效果差于B组和C组,治疗早期C组方案控制血糖显效更快.
목적:비교3충문동이도소30연합용약방안대2형당뇨병환자적혈당파동적영향.방법:장2형당뇨병환자수궤분위3조,A조:문동이도소30주사액매일2차,연합이갑쌍고편치료;B조:문동이도소30주사액매일3차,연합이갑쌍고편치료;C조:문동이도소30주사액매일2차,연합이갑쌍고편화아잡파당편치료.수집료효급안전성수거,진행통계학분석.결과:3충방안공제환자혈당효과이상,료효화안전성상사,조간무현저성차이;단3조간SDBG유현저성차이,B조<C조<A조(F=6.02,P<0.01);A조만찬전혈당치최고(7.14±1.06mmol/L,F=5.63,P<0.05).결론:B조방안혈당파동최소,A조방안만찬전혈당공제효과차우B조화C조,치료조기C조방안공제혈당현효경쾌.
Objective: To compare the blood glucose fluctuation of three combination therapy scheme of insulin aspart 30 in type 2 diabetes subjects. Methods: The subjects with type 2 diabetes were divided into 3 groups randomly. Group A: insulin aspart 30 injection, twice daily, plus metformin tablets; Group B: insulin aspart 30 injection, three times daily, plus metformin tablets; Group C: insulin aspart 30 injection, twice daily, plus metformin and acabose tablets. The efficacy and safety economic data were collected and analyzed. Results:The blood glucose of three groups all dropped obviously, and the efficacy and safety were similar in 3 groups. There is no significant diference among three groups, but there were obvious differences among three groups in SDBG, B group<C group<A group, (F=6.02, P<0.01); blood glucose before supper of group A showed highest, (7.14±1.06mmol/L,F=5.63,P<0.05 ).Conclusion: The blood glucose fluctuation of scheme B showed least. Scheme A showed poorer control of the blood glucose before supper, compared with scheme B and C. Scheme C showed the shortest time to decrease blood glucose in early-stage.