CAJ | 학술논문

目的:系统评价依达拉奉联合奥扎格雷治疗急性缺血性脑卒中的疗效及探讨影响疗效的因素.方法:以“依达拉奉”和“奥扎格雷”为主题词,检索国内2004-2012年期间发表的相关文献;以Jadad评分标准评价纳入的研究质量,以State 11软件对脑卒中患者临床神经功能缺损程度评分量表(NDS)评分和有效率分别进行Meta分析.结果:依达拉奉联合奥扎格雷治疗急性缺血性脑卒中的NDS有效率和NDS评分明显优于奥扎格雷单用组;在限定剂量的亚组中,奥扎格雷的剂量大小可能对结果没有显著性影响.基础治疗是否加用舒血宁、脑复康对结果没有显著性影响.结论:本研究显示依达拉奉联合奥扎格雷治疗急性缺血性脑卒中疗效明显优于单用奥扎格雷.奥扎格雷的剂量可能对NDS有效率、NDS评分没有显著性影响.
목적:계통평개의체랍봉연합오찰격뢰치료급성결혈성뇌졸중적료효급탐토영향료효적인소.방법:이“의체랍봉”화“오찰격뢰”위주제사,검색국내2004-2012년기간발표적상관문헌;이Jadad평분표준평개납입적연구질량,이State 11연건대뇌졸중환자림상신경공능결손정도평분량표(NDS)평분화유효솔분별진행Meta분석.결과:의체랍봉연합오찰격뢰치료급성결혈성뇌졸중적NDS유효솔화NDS평분명현우우오찰격뢰단용조;재한정제량적아조중,오찰격뢰적제량대소가능대결과몰유현저성영향.기출치료시부가용서혈저、뇌복강대결과몰유현저성영향.결론:본연구현시의체랍봉연합오찰격뢰치료급성결혈성뇌졸중료효명현우우단용오찰격뢰.오찰격뢰적제량가능대NDS유효솔、NDS평분몰유현저성영향.
Objective: To systematically evaluate the efficacy of curative effects of treating cerebral ischemic stroke on edaravone combined with ozagrel, and to explore the factors affecting curative effect. Methods: The domestic literature published during 2004~2012 were retrieved by the subject term “edaravone” and “ozagrel”. NDS efficiency and NDS rating were considered as total effective index respectively to develop a meta analysis using software State 11. Results: The group using edaravone and ozagrel is obviously superior to the group using ozagrel only on the NDS efficiency and NDS rating. The dose size of ozagrel does not affect the results obviously. Conclusion: The research showed that the curative effect of combination arm was better than the effect of single-drug arm. The dose size of ozagrel will not affect NDS efficiency and NDS rating obviously.