药品评价
藥品評價
약품평개
DRUG REEVALUATION
2013年
4期
36-42
,共7页
他汀类药物%肝脏安全性%研究进展%合理用药
他汀類藥物%肝髒安全性%研究進展%閤理用藥
타정류약물%간장안전성%연구진전%합리용약
Statins%Hepatic Safety%Research Progress%Rational Drug Use
随着他汀类药物在临床上的广泛使用,他汀类药物的安全性问题也一直备受关注,最常见的问题是血清转氨酶升高.临床对他汀类药物肝脏安全性的认识不足可能限制他汀类药物的一级和二级预防和治疗应用.本文通过对他汀类药物的说明书、相关指南及文献的查阅和分析,总结了他汀类药物肝脏安全性的研究进展,为临床正确认识他汀类药物肝脏安全性及合理选用提供参考.
隨著他汀類藥物在臨床上的廣汎使用,他汀類藥物的安全性問題也一直備受關註,最常見的問題是血清轉氨酶升高.臨床對他汀類藥物肝髒安全性的認識不足可能限製他汀類藥物的一級和二級預防和治療應用.本文通過對他汀類藥物的說明書、相關指南及文獻的查閱和分析,總結瞭他汀類藥物肝髒安全性的研究進展,為臨床正確認識他汀類藥物肝髒安全性及閤理選用提供參攷.
수착타정류약물재림상상적엄범사용,타정류약물적안전성문제야일직비수관주,최상견적문제시혈청전안매승고.림상대타정류약물간장안전성적인식불족가능한제타정류약물적일급화이급예방화치료응용.본문통과대타정류약물적설명서、상관지남급문헌적사열화분석,총결료타정류약물간장안전성적연구진전,위림상정학인식타정류약물간장안전성급합리선용제공삼고.
Statins safety has attracted considerable attention all along with the wide use of statins in clinic, most of which were elevations in serum aminotransferase levels. Current insufficient recognition of hepatic safety of statins possibly limits the utilization of statins in high risk population of cardiovascular disease. By consulting and analyzing the instructions of statins, related guidelines and literature, the progress on hepatic safety of statins was summarized in order to provide reference for correct understanding of hepatic safety of statins in clinic and rational selection of statins.
