CAJ | 학술논문

背景与目的:肌层浸润性膀胱癌标准治疗为根治性膀胱切除术,对于部分不能耐受或不愿根治的患者可行保留膀胱治疗.本文拟探讨膀胱部分切除术联合化疗治疗肌层浸润性膀胱癌的疗效,分析相关影响因素及其应用价值.方法:收集2002年1月—2005年4月期间行膀胱部分切除术(partial cystectomy,PC)联合化疗(PC组)的52例肌层浸润性膀胱癌患者临床资料,对比同期47例根治性膀胱切除术(radical cystectomy, RC)的患者(RC组)总生存率(overall survival,OS)并进行统计分析.结果:PC组和RC组的OS差异无统计学意义(P>0.05),但T3期、肿瘤复发患者的OS PC组明显低于RC组(P<0.05).结论:对于高选择性的患者,膀胱部分切除术联合化疗可作为治疗浸润性膀胱癌的有效方案.
배경여목적:기층침윤성방광암표준치료위근치성방광절제술,대우부분불능내수혹불원근치적환자가행보류방광치료.본문의탐토방광부분절제술연합화료치료기층침윤성방광암적료효,분석상관영향인소급기응용개치.방법:수집2002년1월—2005년4월기간행방광부분절제술(partial cystectomy,PC)연합화료(PC조)적52례기층침윤성방광암환자림상자료,대비동기47례근치성방광절제술(radical cystectomy, RC)적환자(RC조)총생존솔(overall survival,OS)병진행통계분석.결과:PC조화RC조적OS차이무통계학의의(P>0.05),단T3기、종류복발환자적OS PC조명현저우RC조(P<0.05).결론:대우고선택성적환자,방광부분절제술연합화료가작위치료침윤성방광암적유효방안.
Background and purpose:For muscle-invasive bladder caner patients, the recommended treatment is radical cystectomy. While some patients are not suitable or unwilling to this treatment, bladder preserving treatment provides another choice. This research aimed to assess the curative effect, influencing factors of partial cystectomy plus chemotherapy for muscle-invasive bladder cancer. Methods:From Jan. 2002 to Apr. 2005, 52 patients with muscle-invasive bladder cancer underwent partial cystectomy plus chemotherapy (PC group), contrast to 47 patients which underwent radical cystectomy (RC group). The overall survival rates(OS) of the two groups were analyzed. Results:There is no significant difference of overall survival between the two groups (P=0.279). For stage T3 and recurrent patients the PC group had significantly lower survival rates than RC group (P=0.048). Conclusion:Partial cystectomy plus chemotherapy provides a choice for the treatment of muscle-invasive bladder cancer.