CAJ | 학술논문

转移是肿瘤致死的一个重要因素,其发生需要多基因参与、多步骤调控,相关基因及其作用机制的发现对肿瘤转移的预防与治疗具有重要意义.高迁移率族蛋白B1(high mobility group box 1,HMGB1)是一种非组蛋白染色质结合蛋白,在DNA复制、修复、重组和基因转录中起重要作用,在细胞损伤和炎症发生时释放至胞外参与信号转导,调节细胞的生长和分化等.近年研究表明,HMGB1在多种肿瘤细胞和组织中高表达,增强肿瘤细胞的增殖、侵袭和转移,促进肿瘤的发生、发展,提示HMGB1有可能成为治疗和预防肿瘤转移的靶标.现就HMGB1在肿瘤转移中的作用及其机制的研究进展作一综述.
전이시종류치사적일개중요인소,기발생수요다기인삼여、다보취조공,상관기인급기작용궤제적발현대종류전이적예방여치료구유중요의의.고천이솔족단백B1(high mobility group box 1,HMGB1)시일충비조단백염색질결합단백,재DNA복제、수복、중조화기인전록중기중요작용,재세포손상화염증발생시석방지포외삼여신호전도,조절세포적생장화분화등.근년연구표명,HMGB1재다충종류세포화조직중고표체,증강종류세포적증식、침습화전이,촉진종류적발생、발전,제시HMGB1유가능성위치료화예방종류전이적파표.현취HMGB1재종류전이중적작용급기궤제적연구진전작일종술.
Metastasis is the major cause of death from cancer. Cancer metastasis is a complex multi-step process, in which multiple genes participate. This study aimed to find the related genes and understand their role and mechanisms would be crucial for prevention and treatment of cancer metastasis. High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which is implicated in diverse biological processes including DNA replication, repair, recombination and transcription. During cell damage and inflammation, HMGB1 can be released into the microenvironment to participate in extracellular signalling transduction, then regulate cell growth and differentiation. Recent studies showed that HMGB1 was highly expressed in many kinds of cancer cells and tissues, which promoted cancer development by enhancing cell proliferation, migration and invasion. These suggested that HMGB1 may represent a potential target for the therapeutic intervention in cancer. In this paper, we reviewed the role of HMGB1 in cancer metastasis and the mechanisms involved.