CAJ | 학술논문

背景与目的:空芯针穿刺(core? needle? biopsy,CNB)在临床应用于乳腺癌的术前诊断,但其是否会增加肿瘤的复发风险值得研究.本研究旨在比较术前CNB与开放性手术活检(excisional? biopsy,EB)对乳腺癌患者预后的影响.方法:回顾性分析我院367例早期乳腺癌患者资料,根据术前诊断方法将患者分为CNB组(n=89)和EB组(n=278).比较两组的临床病理特征及无病生存率(disease? free? survival,DFS)差异.结果:CNB组患者的肿瘤直径较EB组大,但并不影响患者的预后,两组患者的DFS无显著差异(HR=1.211,95%CI:0.517~2.840).活检与根治性手术的间隔时间长短同样不影响患者的DFS(HR=0.792,95%CI:0.418~1.943).结论:与EB相比,CNB不影响患者的预后,值得在乳腺癌患者术前诊断中推广应用.
배경여목적:공심침천자(core? needle? biopsy,CNB)재림상응용우유선암적술전진단,단기시부회증가종류적복발풍험치득연구.본연구지재비교술전CNB여개방성수술활검(excisional? biopsy,EB)대유선암환자예후적영향.방법:회고성분석아원367례조기유선암환자자료,근거술전진단방법장환자분위CNB조(n=89)화EB조(n=278).비교량조적림상병리특정급무병생존솔(disease? free? survival,DFS)차이.결과:CNB조환자적종류직경교EB조대,단병불영향환자적예후,량조환자적DFS무현저차이(HR=1.211,95%CI:0.517~2.840).활검여근치성수술적간격시간장단동양불영향환자적DFS(HR=0.792,95%CI:0.418~1.943).결론:여EB상비,CNB불영향환자적예후,치득재유선암환자술전진단중추엄응용.
? Background and purpose:Core needle biopsy (CNB) has been used in preoperative diagnosis of breast cancer. However CNB increases the risk of recurrence is unclear. In this research, we compared the impact of CNB and EB on the DFS of breast cancer patients.? Methods:We retrospectively analyzed 367 female patients with early breast cancer. The patients were divided into preopertative CNB group (n=89) and EB group (n=278). DFS was compared between these two groups after 34.75 months median follow-up. Results:Patients with larger tumor size were more common in the CNB group than in the EB group. DFS (HR=1.211, 95%CI: 0.517-2.840) was not significantly different between the two groups. A short interval between biopsy and surgical excision did not influence the DFS either (HR=0.792, 95%CI: 0.418-1.943). Conclusion:Compared with EB, CNB can minimize the invasion and reduce the cost with no detrimental impact on DFS. It is recommended to be widely utilized in clinical practice.