中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2012年
11期
860-863
,共4页
王群%杨志刚%许辉东%邢戌健
王群%楊誌剛%許輝東%邢戌健
왕군%양지강%허휘동%형술건
促甲状腺激素%甲状腺癌%甲状腺良性肿瘤
促甲狀腺激素%甲狀腺癌%甲狀腺良性腫瘤
촉갑상선격소%갑상선암%갑상선량성종류
Thyroid stimulating hormone%Thyroid cancer%Benign thyroid tumor
背景与目的:血清促甲状腺激素(thyroid? stimulating? hormone,TSH)水平与甲状腺癌患者预后密切相关,TSH水平高可明显增加甲状腺癌患者的复发率及死亡率,本研究探讨TSH水平与甲状腺癌发病的关系.方法:回顾性分析2006年6月—2012年6月我院收治的606例拟行各类甲状腺手术患者的临床资料,检测患者术前血清TSH水平,并根据血清TSH水平分为5组,其中0.51~2.43?mIU/L组、2.44~4.36?mIU/L组、4.37~6.27?mIU/L组各153例,<0.51?mIU/L组47例,>6.27?mIU/L组100例.采用单因素与多因素的方法探讨血清TSH水平与甲状腺癌发病的相关性.结果:年龄<18岁、≥65岁组的甲状腺癌患者所占比例(56.3%、46.9%)显著高于18~39岁及40~64岁患者(28.5%、26.8%),男性甲状腺癌患者所占比例(48.3%)显著高于女性患者(17.0%),单个结节患者甲状腺癌所占比例(49.5%)显著高于多个结节患者(18.8%),差异均有统计学意义(P<0.05).随着血清TSH水平的升高,甲状腺癌患者所占比例也升高,差异有统计学意义(P<0.05).Logistic回归分析结果显示,男性、单个结节及血清TSH水平高均是甲状腺癌发病的独立危险因素(P<0.05).结论:男性、单个结节及术前血清TSH水平可以作为甲状腺癌发病风险的预测指标.
揹景與目的:血清促甲狀腺激素(thyroid? stimulating? hormone,TSH)水平與甲狀腺癌患者預後密切相關,TSH水平高可明顯增加甲狀腺癌患者的複髮率及死亡率,本研究探討TSH水平與甲狀腺癌髮病的關繫.方法:迴顧性分析2006年6月—2012年6月我院收治的606例擬行各類甲狀腺手術患者的臨床資料,檢測患者術前血清TSH水平,併根據血清TSH水平分為5組,其中0.51~2.43?mIU/L組、2.44~4.36?mIU/L組、4.37~6.27?mIU/L組各153例,<0.51?mIU/L組47例,>6.27?mIU/L組100例.採用單因素與多因素的方法探討血清TSH水平與甲狀腺癌髮病的相關性.結果:年齡<18歲、≥65歲組的甲狀腺癌患者所佔比例(56.3%、46.9%)顯著高于18~39歲及40~64歲患者(28.5%、26.8%),男性甲狀腺癌患者所佔比例(48.3%)顯著高于女性患者(17.0%),單箇結節患者甲狀腺癌所佔比例(49.5%)顯著高于多箇結節患者(18.8%),差異均有統計學意義(P<0.05).隨著血清TSH水平的升高,甲狀腺癌患者所佔比例也升高,差異有統計學意義(P<0.05).Logistic迴歸分析結果顯示,男性、單箇結節及血清TSH水平高均是甲狀腺癌髮病的獨立危險因素(P<0.05).結論:男性、單箇結節及術前血清TSH水平可以作為甲狀腺癌髮病風險的預測指標.
배경여목적:혈청촉갑상선격소(thyroid? stimulating? hormone,TSH)수평여갑상선암환자예후밀절상관,TSH수평고가명현증가갑상선암환자적복발솔급사망솔,본연구탐토TSH수평여갑상선암발병적관계.방법:회고성분석2006년6월—2012년6월아원수치적606례의행각류갑상선수술환자적림상자료,검측환자술전혈청TSH수평,병근거혈청TSH수평분위5조,기중0.51~2.43?mIU/L조、2.44~4.36?mIU/L조、4.37~6.27?mIU/L조각153례,<0.51?mIU/L조47례,>6.27?mIU/L조100례.채용단인소여다인소적방법탐토혈청TSH수평여갑상선암발병적상관성.결과:년령<18세、≥65세조적갑상선암환자소점비례(56.3%、46.9%)현저고우18~39세급40~64세환자(28.5%、26.8%),남성갑상선암환자소점비례(48.3%)현저고우녀성환자(17.0%),단개결절환자갑상선암소점비례(49.5%)현저고우다개결절환자(18.8%),차이균유통계학의의(P<0.05).수착혈청TSH수평적승고,갑상선암환자소점비례야승고,차이유통계학의의(P<0.05).Logistic회귀분석결과현시,남성、단개결절급혈청TSH수평고균시갑상선암발병적독립위험인소(P<0.05).결론:남성、단개결절급술전혈청TSH수평가이작위갑상선암발병풍험적예측지표.
? Background and purpose:Serum thyroid stimulating hormone (TSH) level and the prognosis of patients with thyroid cancer is closely related, and high level TSH can obviously increase the recurrence rate and mortality in patients with thyroid cancer. In our study we explored the relationship between serum thyroid stimulating hormone (TSH) concentration and thyroid cancer incidence.? Methods:Clinical data of 406 patients who were scheduled for surgical treatment were retrospectively analyzed, the level of serum TSH before the surgery was detected, and according to the level of serum TSH, all the cases were divided into 5 groups, including 0.51-2.43 mIU/L group, 2.44-4.36 mIU/L group, 4.37-6.27 mIU/L group with 153 cases respectively, and <0.51 mIU/L group with 47 cases,>6.27 mIU/L group with 100 cases. Univariate analysis and multivariate analysis were used to explore the association between serum TSH with thyroid cancer. Results:The proportion of thyroid cancer in groups of age younger than 18 years and older than 65 years were 56.3%, 46.9%, which were significantly higher than those in groups of age in 18-39 (28.5%) and 40-64 (26.8%, P<0.05).The proportion of thyroid cancer of male patients was 48.3%, which was significantly higher than that in female patients (17.0%, P<0.05). The proportion of thyroid cancer of patients with single nodule was 49.5%, significantly higher than the patients with multiple nodules 18.8% (P<0.05). The proportion of thyroid cancer of patients was increased with the increasing serum TSH level (P<0.05). By Logistic regression analysis, male, single nodule and high serum TSH level were all independent risk factors of thyroid cancer incidence (P<0.05). Conclusion:High serum TSH level, male and single nodule can be used as a risk predictor for severity of thyroid cancer incidence.
