CAJ | 학술논문

目的:探讨VEGF在子宫内膜癌组织中的表达情况及其与子宫内膜癌发展及转移的关系.方法:采用免疫组织化S-P法检测VEGF 的表达分析其在组织中表达的差异,及其与临床病理特征的关系,结果:用SPSS12.0统计软件进行统计分析,在子宫内膜癌组织中VEGF的阳性表达率为71.4%,在不同组织病理分级中的表达结果:G1级的阳性率为76.6%,G2级的阳性表达率为76.1%,G3级的阳性表达率为41.6%,三者之间有显著差异(P<0.05);子宫肌层浸润<1/2病例的阳性率为58.8%,肌层浸润≥1/2者阳性率为86.7%,两者之间有显著差异(P<0.05);淋巴结转移阴性的病例中的阳性率为57.4%,淋巴结转移阳性者为88.5%,两者之间有显著差异(P<0.05),手术病理分期Ⅰ期的阳性率为66.7%,Ⅱ期的阳性率为71.8%;Ⅲ期的阳性率为84.6%,三者之间没有明显差异(P﹤0.05).结论: VEGF在子宫内膜癌组织中的阳性表达为胞浆棕黄色染色,VEGF在子宫内膜癌组织中的阳性表达率随病理学分期和组织学分级的升高而增高.VEGF与子宫内膜癌的发生、发展、侵袭及转移中发挥作用.
목적:탐토VEGF재자궁내막암조직중적표체정황급기여자궁내막암발전급전이적관계.방법:채용면역조직화S-P법검측VEGF 적표체분석기재조직중표체적차이,급기여림상병리특정적관계,결과:용SPSS12.0통계연건진행통계분석,재자궁내막암조직중VEGF적양성표체솔위71.4%,재불동조직병리분급중적표체결과:G1급적양성솔위76.6%,G2급적양성표체솔위76.1%,G3급적양성표체솔위41.6%,삼자지간유현저차이(P<0.05);자궁기층침윤<1/2병례적양성솔위58.8%,기층침윤≥1/2자양성솔위86.7%,량자지간유현저차이(P<0.05);림파결전이음성적병례중적양성솔위57.4%,림파결전이양성자위88.5%,량자지간유현저차이(P<0.05),수술병리분기Ⅰ기적양성솔위66.7%,Ⅱ기적양성솔위71.8%;Ⅲ기적양성솔위84.6%,삼자지간몰유명현차이(P﹤0.05).결론: VEGF재자궁내막암조직중적양성표체위포장종황색염색,VEGF재자궁내막암조직중적양성표체솔수병이학분기화조직학분급적승고이증고.VEGF여자궁내막암적발생、발전、침습급전이중발휘작용.
Objective:To evaluate the expression of VEGF in the tissue of endometrial cancer ,and investigate the relationship between the expression of VEGF and the development ,metastasis of endometrial cancer..Methods:analyze the relationship between the expression and the clinical pathological characteristics,and analyze the expression of VEGF in the tissue of endometrial cancer by immunocytochemisory.Results:do statistical analysis with the results above by SPSS 12.0 statistic software.the positive rate of VEGF of expression is 71.4%in the tissue of endometrial cancer.,VEGF can be expressed differently with different pathological grate.Grate 1 is 75.0%grate 2 is 76.1%,grate 3 is 41.6%.and there is obvious distinction among them(P<0.05).The positive rate of VEGF expression is 58.8% when not more than 50 precen myometrium is infiltrated in peritoneal in peritoneal fliud of endometrial cancer ,and 86.7%is expression when more than 50 precent myometrium is infiltrated .there is obvious distinction between them(P<0.05).the positive rate of VEGF can be expressed differently with different pathological stage. stage 1 is 66.7%,stage 2 is 75.0%,stage 3 is 83.3%.and there is obvious distinction among them.(P<0.05).Conclusion:VEGF were highe expressed in tissue carcinoma of endomertrium, The results suggested the expression of VEGF has no relation with lymph node matastasis. VEGF played a key role in carcinogenesis,development,infiltration and metastasis of carcinoma of endometrium.