中国保健营养(中旬刊)
中國保健營養(中旬刊)
중국보건영양(중순간)
China Hwalth Care & nutrition
2012年
z2期
35
,共1页
喻化%张华坤%姜秀举%花芃
喻化%張華坤%薑秀舉%花芃
유화%장화곤%강수거%화봉
奥氮平%男性%精神分裂症%疗效%全病程管理
奧氮平%男性%精神分裂癥%療效%全病程管理
오담평%남성%정신분렬증%료효%전병정관리
Olanzapine%Male%Schizophrenia%Efficacy%Integrated case management
目的:评价国产奥氮平长期治疗男性首发精神分裂症的疗效及不良反应.方法:本研究采用自然观察研究方法,结合全病程管理模式对研究对象进行1年的随访研究.共50例符合国际疾病分类第十次修订本(ICD-10)的男性首发精神分裂症纳入本研究,给予可变剂量的国产奥氮平治疗.采用阳性症状与阴性症状量表(PANSS)评估疗效,采用副反应量表(TESS)评定副反应.结果:治疗第3,6,12月末的有效率分别为84%(42/50),89%(44/49),89%(44/49),1年末有1例脱落,共有5例复发,奥氮平的平均持续治疗时间(10.4±4.7)月,不良反应发生率≥10%为体重增加,嗜睡,乏力.结论:奥氮平长期治疗男性首发精神分裂症有效,安全.
目的:評價國產奧氮平長期治療男性首髮精神分裂癥的療效及不良反應.方法:本研究採用自然觀察研究方法,結閤全病程管理模式對研究對象進行1年的隨訪研究.共50例符閤國際疾病分類第十次脩訂本(ICD-10)的男性首髮精神分裂癥納入本研究,給予可變劑量的國產奧氮平治療.採用暘性癥狀與陰性癥狀量錶(PANSS)評估療效,採用副反應量錶(TESS)評定副反應.結果:治療第3,6,12月末的有效率分彆為84%(42/50),89%(44/49),89%(44/49),1年末有1例脫落,共有5例複髮,奧氮平的平均持續治療時間(10.4±4.7)月,不良反應髮生率≥10%為體重增加,嗜睡,乏力.結論:奧氮平長期治療男性首髮精神分裂癥有效,安全.
목적:평개국산오담평장기치료남성수발정신분렬증적료효급불량반응.방법:본연구채용자연관찰연구방법,결합전병정관리모식대연구대상진행1년적수방연구.공50례부합국제질병분류제십차수정본(ICD-10)적남성수발정신분렬증납입본연구,급여가변제량적국산오담평치료.채용양성증상여음성증상량표(PANSS)평고료효,채용부반응량표(TESS)평정부반응.결과:치료제3,6,12월말적유효솔분별위84%(42/50),89%(44/49),89%(44/49),1년말유1례탈락,공유5례복발,오담평적평균지속치료시간(10.4±4.7)월,불량반응발생솔≥10%위체중증가,기수,핍력.결론:오담평장기치료남성수발정신분렬증유효,안전.
Objective:To evaluate the long-term effectiveness of the domestic olanzapine in the treatment of patients with the male first-episode schizophrenia ,meanwhile to evaluate the adverse events. Methods:It was a one year follow-up study with integrated case management and naturalistic observation. Fifty patients of the male first-episode schizophrenia were included. Patients met ICD-10 criteria for schizophrenia and were treated with the domestic olanzapine, the dose of which was not fixed. Clinical status was assessed with the Positive and Negative Syndrom Scale(PANSS) and the Treatment Emergent Symptom(TESS). Results:The response rates at the end of 3,6,12 months were 84%(42/50),89%(44/49),89%(44/49),One patients only completed partial follow-up assessments. There 49 patients who achieved response, and 5 of whom relapsed. The mean time to the discontinuation was (10.4±4.7) months(range:1~12 months). The adverse events reported in≥10%of patients were weight gain, somnolence, weak.. Conclusions:Thedomestic olanzapine was effective for patients with the male first-episode schizophrenia and safe.