CAJ | 학술논문

目的观察电针联合依达拉奉对糖尿病周围神经病大鼠坐骨神经传导速度和氧化应激的影响.方法 SD大鼠60只,选取10只作为正常组.其余予一次性链脲佐菌素腹腔注射造模.抽取48只模型大鼠,分为电针组、依达拉奉组、联合组和模型组各12只.造模后4周、8周,测试各大鼠摆尾阈值、血清超氧化物酶歧化酶(SOD)活性和丙二醛(MDA)浓度及坐骨神经传导速度.结果造模8周时,电针组、依达拉奉组和联合组运动神经传导速度明显高于模型组(P<0.01),SOD活性明显高于模型组(P<0.01),MDA浓度明显低于模型组(P<0.01);而联合组明显优于电针组、依达拉奉组(P<0.01).结论电针及依达拉奉均能有效抑制糖尿病周围神经病大鼠的氧化应激反应,改善坐骨神经传导速度,联合应用效果更佳.
목적관찰전침연합의체랍봉대당뇨병주위신경병대서좌골신경전도속도화양화응격적영향.방법 SD대서60지,선취10지작위정상조.기여여일차성련뇨좌균소복강주사조모.추취48지모형대서,분위전침조、의체랍봉조、연합조화모형조각12지.조모후4주、8주,측시각대서파미역치、혈청초양화물매기화매(SOD)활성화병이철(MDA)농도급좌골신경전도속도.결과조모8주시,전침조、의체랍봉조화연합조운동신경전도속도명현고우모형조(P<0.01),SOD활성명현고우모형조(P<0.01),MDA농도명현저우모형조(P<0.01);이연합조명현우우전침조、의체랍봉조(P<0.01).결론전침급의체랍봉균능유효억제당뇨병주위신경병대서적양화응격반응,개선좌골신경전도속도,연합응용효과경가.
Objective To observe the effects of electroacupuncture combined with edaravone on the conduction velocity of sciatic nerve and oxidative stress in rats with diabetic peripheral neuropathy. Methods 60 Sprague Dawley (SD) rats were included. 10 of them were se-lected as normal group. The other rats were modeled as diabetic peripheral neuropathy with streptozotocin. 48 of them were randomly select-ed and divided into electroacupuncture group (n=12), edaravone group (n=12), electroacupuncture+edaravone group (n=12), and model group (n=12). The threshold temperature for wave tail was tested, the levels of superoxidase dismutase (SOD) and malonaldehyde (MDA) were determined, and the conduction velocity of sciatic nerve were measured, before, and 4 and 8 weeks after modeling. Results 8 weeks af-ter modeling, the conduction velocity and SOD increased in the electroacupuncture group, edaravone group and electroacupuncture+edara-vone group compared with the model group (P<0.01), with the MDA decrease (P<0.01), while it was improved more in the electroacupunc-ture+edaravone group than in the electroacupuncture group or the edaravone group (P<0.01). Conclusion Both electroacupuncture and edar-avone can inhibit oxidative stress and improve nerve conduction velocity of the sciatic nerve in rats with diabetic peripheral neuropathy, and it is more effective of combination.