CAJ | 학술논문

帕金森病是人类最常见的神经退行性运动障碍性疾病之一,其特征是中脑黑质致密部多巴胺能神经元变性丢失,纹状体内多巴胺水平降低,进而引起震颤、肌肉僵直、运动迟缓和姿势步态失调的症状.帕金森病的病理机制复杂,病因目前仍不清楚.但近年来,炎症反应在帕金森病中的作用引起人们的广泛关注,小胶质细胞的激活以及炎性因子的高表达参与帕金森病的发生、发展过程.应用抗炎药物延缓或阻止帕金森病的发生、发展已成为该领域新的研究热点.本文就帕金森病中的炎症机制以及抗炎药物的进展进行综述.
파금삼병시인류최상견적신경퇴행성운동장애성질병지일,기특정시중뇌흑질치밀부다파알능신경원변성주실,문상체내다파알수평강저,진이인기진전、기육강직、운동지완화자세보태실조적증상.파금삼병적병리궤제복잡,병인목전잉불청초.단근년래,염증반응재파금삼병중적작용인기인문적엄범관주,소효질세포적격활이급염성인자적고표체삼여파금삼병적발생、발전과정.응용항염약물연완혹조지파금삼병적발생、발전이성위해영역신적연구열점.본문취파금삼병중적염증궤제이급항염약물적진전진행종술.
Parkinson's disease (PD) is one of the most prevalent neurodegenerative movement disorder in human being, characterized by progressive degeneration and lost of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc), causing low level of DA in the nigrostriatal pathway, eventually leading to motor dysfunctions including tremor, rigidity, bradykinesia, and postural instability. The pathology of PD is complex and the etiology remains poorly understood. In recent years, inflammation has been suggested to be in-volved in the occurrence and development of PD, by activation of microglia and overexpression of the inflammatory factors. And anti-in-flammatory drugs has been developed to delay or prevent the progressive course of PD, becoming a new hotspot in treatment of PD. In this review, the latest progresses on the inflammatory mechanisms and anti-inflammatory treatments of PD was introduced.