CAJ | 학술논문

目的观察足三里穴位注射胞二磷胆碱疗法对脑外伤大鼠学习记忆功能的影响.方法采用改进的Feeney法建立大鼠脑外伤模型.40只大鼠随机分为假手术组、对照组、穴位注水组、腹腔给药组和穴位注药组,每组8只.假手术组不造模,腹腔注射等体积生理盐水.其他组造模后,对照组:腹腔注射等体积生理盐水;穴位注水组:足三里穴注射等体积生理盐水;腹腔给药组:胞二磷胆碱500 mg/kg腹腔注射;穴位注药组:胞二磷胆碱以生理盐水溶解为500 mg/ml,500 mg/kg足三里穴注射.连续14 d.通过水迷宫实验和避暗实验测定大鼠学习记忆功能.结果在Morris水迷宫实验中,除假手术组外,穴位注药组大鼠逃避潜伏期短于其他组(P<0.05);在避暗实验中,穴位注药组大鼠学习记忆潜伏期较其他组长(P<0.05),错误次数较少.结论穴位注射胞二磷胆碱能明显改善脑外伤大鼠的学习记忆功能.
목적관찰족삼리혈위주사포이린담감요법대뇌외상대서학습기억공능적영향.방법채용개진적Feeney법건립대서뇌외상모형.40지대서수궤분위가수술조、대조조、혈위주수조、복강급약조화혈위주약조,매조8지.가수술조불조모,복강주사등체적생리염수.기타조조모후,대조조:복강주사등체적생리염수;혈위주수조:족삼리혈주사등체적생리염수;복강급약조:포이린담감500 mg/kg복강주사;혈위주약조:포이린담감이생리염수용해위500 mg/ml,500 mg/kg족삼리혈주사.련속14 d.통과수미궁실험화피암실험측정대서학습기억공능.결과재Morris수미궁실험중,제가수술조외,혈위주약조대서도피잠복기단우기타조(P<0.05);재피암실험중,혈위주약조대서학습기억잠복기교기타조장(P<0.05),착오차수교소.결론혈위주사포이린담감능명현개선뇌외상대서적학습기억공능.
Objective To explore the effects of citicoline injection into Zusanli point (ST36) on learning and memory function of rats af-ter traumatic brain injury (TBI). Methods The model was induced with the improved Feeney method. The rats were randomly divided into 5 groups:sham-operation group, control group, acupuncture point saline injection group, intraperitoneal drug injection group and acupuncture point drug injection group with 8 rats in each group. The rats in the acupuncture point drug or saline injection group were treated with acu-puncture injection of citicoline or saline daily. The rats in the intraperitoneal drug injection group and control group were treated with intra-peritoneal injection of citicoline or saline daily. The treatment continued for 14 d. The learning and memory function was evaluated with the Morris water maze test and passive avoidance test. Results Acupuncture point injection of citicoline can significantly shorten the escape la-tent period of TBI rats in Morris water tests and extend the latent period of learning and memory of TBI rats (P<0.05). Conclusion Acupunc-ture point injection is effective on the recovery of learning and memory function of rats after TBI.