CAJ | 학술논문

目的采用Meta分析评价综合康复训练对精神分裂症患者的康复疗效.方法计算机检索PubMed(2001~2011)、FM-JS外文全文数据库(EMCC,1995~2011)、中国期刊全文数据库(CNKI,1989~2011)、维普中文科技期刊全文数据库(VIP,1989~2011)、中国生物医学文献数据库(CBM,1989~2011),全面收集有关于综合康复训练治疗精神分裂症的随机对照试验或临床对照试验文献.按照Jadad量表评价纳入研究文献质量,提取有效数据,采用RevMan 5.0软件进行Meta分析.结果共检索到国内外文献596篇,经排查后,纳入研究质量较低的随机或临床对照试验文献共16篇.Meta分析结果显示:与常规护理/管理组比较,综合康复训练组阳性症状和阴性症状量表(PANSS)评分[加权均数差(WMD)=-9.21,95%CI(-10.83,-7.59), Z=11.6, P<0.00001]、日常生活活动能力量表(ADL)评分[WMD=-5.84,95%CI(-8.74,-2.94), Z=3.94, P<0.0001]、护士用住院患者观察量表(NOSIE)总消极因素评分[WMD=-13.60,95%CI(-22.41,-4.80), Z=3.03, P=0.002]、NOSIE总评分[WMD=27.50,95%CI(16.18,38.81), Z=4.76, P<0.00001]疗效较优.社会功能缺陷筛选量表(SDSS)评分[WMD=-2.50,95%CI(-5.33,0.33), Z=1.73, P=0.08]和NOSIE总积极因素评分[WMD=15.00,95%CI(-2.06,32.06), Z=1.72, P=0.08],两组间无显著性差异.结论在常规治疗的基础上,综合康复训练能减轻精神分裂症患者的精神症状,提高日常生活能力,降低消极症状,提高患者的生活质量.
목적채용Meta분석평개종합강복훈련대정신분렬증환자적강복료효.방법계산궤검색PubMed(2001~2011)、FM-JS외문전문수거고(EMCC,1995~2011)、중국기간전문수거고(CNKI,1989~2011)、유보중문과기기간전문수거고(VIP,1989~2011)、중국생물의학문헌수거고(CBM,1989~2011),전면수집유관우종합강복훈련치료정신분렬증적수궤대조시험혹림상대조시험문헌.안조Jadad량표평개납입연구문헌질량,제취유효수거,채용RevMan 5.0연건진행Meta분석.결과공검색도국내외문헌596편,경배사후,납입연구질량교저적수궤혹림상대조시험문헌공16편.Meta분석결과현시:여상규호리/관리조비교,종합강복훈련조양성증상화음성증상량표(PANSS)평분[가권균수차(WMD)=-9.21,95%CI(-10.83,-7.59), Z=11.6, P<0.00001]、일상생활활동능역량표(ADL)평분[WMD=-5.84,95%CI(-8.74,-2.94), Z=3.94, P<0.0001]、호사용주원환자관찰량표(NOSIE)총소겁인소평분[WMD=-13.60,95%CI(-22.41,-4.80), Z=3.03, P=0.002]、NOSIE총평분[WMD=27.50,95%CI(16.18,38.81), Z=4.76, P<0.00001]료효교우.사회공능결함사선량표(SDSS)평분[WMD=-2.50,95%CI(-5.33,0.33), Z=1.73, P=0.08]화NOSIE총적겁인소평분[WMD=15.00,95%CI(-2.06,32.06), Z=1.72, P=0.08],량조간무현저성차이.결론재상규치료적기출상,종합강복훈련능감경정신분렬증환자적정신증상,제고일상생활능력,강저소겁증상,제고환자적생활질량.
Objective To evaluate the effects of comprehensive rehabilitation training on the patients with schizophrenia by Meta-analy-sis. Methods Articles were searched form PubMed (2001 to 2011), EMCC(1995 to 2011), CNKI(1989 to 2011), VIP(1989 to 2011), and CBM(1989 to 2011), which were randomized controlled trials (RCTs) or controlled clinical trials (CCTs) about comprehensive rehabilitation training for schizophrenia. Quality of included articles was assessed with Jadad Scale, and the available data were analyzed with RevMan 5.0 software. Results 596 related articles were identified, but only 16 eligible articles were included. All the trials were of low quality. Me-ta-analysis showed that compared comprehensive rehabilitation training could improve the scores of Positive and Negative Syndrome Scale (PANSS) [Weighted Mean Difference (WMD) =-9.21, 95% CI(-10.83,-7.59), Z=11.6, P<0.00001], activites of daily living (ADL) [WMD=-5.84, 95%CI(-8.74,-2.94), Z=3.94, P<0.0001], Nurses' Observation Scale for Inpatient Evaluation (NOSIE) total score [WMD=27.50, 95%CI(16.18,38.81), Z=4.76, P<0.00001] and total score of negative factors [WMD=-13.60, 95%CI(-22.41,-4.80), Z=3.03, P=0.002], compared with those in routine care/management group. There was no significant difference between both groups in So-cial Disability Screening Schedule (SDSS) [WMD=-2.50, 95%CI(-5.33, 0.33), Z=1.73, P=0.08] and NOSIE total positive factor score [WMD=15.00, 95%CI(-2.06, 32.06), Z=1.72, P=0.08]. Conclusion Comprehensive rehabilitation training can reduce the positive and negative symptoms, improving the ability of daily living and quality of life.