CAJ | 학술논문

蛋白质构象病是一类由于蛋白构象错误而引发组织病变的疾病.阿尔兹海默症是一类典型的蛋白质构象病,而关于其相关蛋白,β淀粉样多肽(Aβ)诱发疾病的机理目前有很多种说法,最近发现朊蛋白在Aβ诱发阿尔兹海默症的过程中有着较为重要的作用.综述了朊蛋白与Aβ的主要作用方式以及这些相互作用与阿尔兹海默症关系研究的最新研究进展.
단백질구상병시일류유우단백구상착오이인발조직병변적질병.아이자해묵증시일류전형적단백질구상병,이관우기상관단백,β정분양다태(Aβ)유발질병적궤리목전유흔다충설법,최근발현원단백재Aβ유발아이자해묵증적과정중유착교위중요적작용.종술료원단백여Aβ적주요작용방식이급저사상호작용여아이자해묵증관계연구적최신연구진전.
Alzheimer’s disease is a typical protein conformation disorder disease which is caused by misfolded and toxic cellular proteins. Manymechanismshavebeenproposedexplainingthepathogenesisofβ-amyloid(Aβ).Recentlythecellularprionproteinhasbeen found to be related to the Aβ-induced toxicity. This review mainly focuses on the recent advances about the interactions between Aβ and cellular prionprotein.