CAJ | 학술논문

目的探讨人脑胶质瘤质子磁共振波谱(1HMRS)的特点及临床意义.方法22例脑胶质瘤患者术前行MRI检查的同时作1HMRS 分析,并以20例对侧正常的相应部位作为自身对照,比较 N-乙酰门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)和乳酸(Lac)以及 Cho/Cr、NAA/Cr、NAA/Cho 比值的变化.结果与对照脑区比,脑胶质瘤在1HMRS 上均表现为明显增高的 Cho 峰(P<0.01),NAA、Cr峰下降或消失(P<0.05),Cho/Cr比值升高,NAA/Cr比值降低(P<0.05);它们的变化并与肿瘤不同病理级别密切相关,其差异具有显著性(P<0.05).结论1HMRS是研究脑胶质瘤物质和能量代谢的有效方法,能为脑胶质瘤的临床诊断提供帮助.
목적탐토인뇌효질류질자자공진파보(1HMRS)적특점급림상의의.방법22례뇌효질류환자술전행MRI검사적동시작1HMRS 분석,병이20례대측정상적상응부위작위자신대조,비교 N-을선문동안산(NAA)、담감(Cho)、기산(Cr)화유산(Lac)이급 Cho/Cr、NAA/Cr、NAA/Cho 비치적변화.결과여대조뇌구비,뇌효질류재1HMRS 상균표현위명현증고적 Cho 봉(P<0.01),NAA、Cr봉하강혹소실(P<0.05),Cho/Cr비치승고,NAA/Cr비치강저(P<0.05);타문적변화병여종류불동병리급별밀절상관,기차이구유현저성(P<0.05).결론1HMRS시연구뇌효질류물질화능량대사적유효방법,능위뇌효질류적림상진단제공방조.
Objective To investigate gliomas findings on 1HMRS and its clinical application. Methods 1H magnetic resonane spectroscopy (1HMRS) examination were performed in 22 patients with gliomas, of whom, 11 had WHO grades Ⅰ~Ⅱ, 5 WHO grades Ⅲastrocytomas, and 6 glioblastomas. The contralateral normal hemispheres of 20 patients served as control group. Results The top of choline (cho) significantly increased and the tops of N-acetyl-asparate (NAA) and creatine (Cr) significantly decreased on 1HMRS in the gliomas compared to those in the control group (P<0.05). The ratio of Cho/Cr was significantly higher, and the ratios of NAA/Cr and NAA/Cho were significantly lower in the gliomas than those in the control group (P<0.01). Conclusions 1HMRS is an effective method to study substance and energetic metabolism in the gliomas, and helpful to the diagnosis of the gliomas.