中国男科学杂志
中國男科學雜誌
중국남과학잡지
CHINESE JOURNAL OF ANDROLOGY
2012年
11期
33-36
,共4页
杨慎敏%许咏乐%吴惠华%李红%王玮*%顾斌%丁洁%郑爱燕%史轶超%程洪波%沈丽燕
楊慎敏%許詠樂%吳惠華%李紅%王瑋*%顧斌%丁潔%鄭愛燕%史軼超%程洪波%瀋麗燕
양신민%허영악%오혜화%리홍%왕위*%고빈%정길%정애연%사질초%정홍파%침려연
精子注射, 细胞质内%精索静脉曲张%无精子症%妊娠结局
精子註射, 細胞質內%精索靜脈麯張%無精子癥%妊娠結跼
정자주사, 세포질내%정색정맥곡장%무정자증%임신결국
sperm injections, intracytoplasmic%varicocele%azoospermia%pregnancy outcome
目的比较先天性双侧输精管缺如(CBAVD)、精索静脉曲张(VC)、AZFc 缺失这三种病因与相应对照周期卵胞浆内单精子注射(ICSI)治疗的结局.方法比较 CBAVD 组与非 CBAVD 的梗阻性无精子症(non-CBAVD 组),VC 组与非 VC 的严重少、弱精子症(non-VC 组),AZFc 缺失与非 AZFc 缺失的严重少弱精子症(non-AZFc 组)行 ICSI 治疗的受精率、卵裂率、优质胚胎率、累积妊娠率以及其他相关指标.结果各组间的女方年龄差异无统计学意义.CBAVD 组与 non-CBAVD 组比较,受精率为61.36% vs 57.02%(P >0.05),卵裂率100% vs 99.61%(P >0.05),优质胚胎率26.67% vs 48.24%(P <0.001),累积妊娠率52.94% vs 80.56%(P <0.05),CBAVD 组优质胚胎率和累积妊娠率低于 non-CBAVD 组.VC组与 non-VC 组比较,受精率为60.48% vs 66.03%(P >0.05),卵裂率98.02% vs 99.37%(P >0.05),优质胚胎率40.40% vs 38.79%(P >0.05),累积妊娠率60.00% vs 55.56%(P >0.05),VC 组受精率低于 non-VC 组,差异无统计学意义.AZFc 组与 non-AZFc 组相比,受精率为57.14% vs 64.92%(P >0.05),卵裂率100% vs 99.36%(P >0.05),优质胚胎率36.36% vs 41.33%(P >0.05),累积妊娠率66.67% vs 53.70%(P >0.05),差异均无统计学意义.结论 CBAVD 男性 ICSI 优质胚胎率和累积妊娠率降低,VC 和AZFc 缺失对 ICSI 受精率、卵裂率、优质胚胎率和累积妊娠率无明显影响.
目的比較先天性雙側輸精管缺如(CBAVD)、精索靜脈麯張(VC)、AZFc 缺失這三種病因與相應對照週期卵胞漿內單精子註射(ICSI)治療的結跼.方法比較 CBAVD 組與非 CBAVD 的梗阻性無精子癥(non-CBAVD 組),VC 組與非 VC 的嚴重少、弱精子癥(non-VC 組),AZFc 缺失與非 AZFc 缺失的嚴重少弱精子癥(non-AZFc 組)行 ICSI 治療的受精率、卵裂率、優質胚胎率、纍積妊娠率以及其他相關指標.結果各組間的女方年齡差異無統計學意義.CBAVD 組與 non-CBAVD 組比較,受精率為61.36% vs 57.02%(P >0.05),卵裂率100% vs 99.61%(P >0.05),優質胚胎率26.67% vs 48.24%(P <0.001),纍積妊娠率52.94% vs 80.56%(P <0.05),CBAVD 組優質胚胎率和纍積妊娠率低于 non-CBAVD 組.VC組與 non-VC 組比較,受精率為60.48% vs 66.03%(P >0.05),卵裂率98.02% vs 99.37%(P >0.05),優質胚胎率40.40% vs 38.79%(P >0.05),纍積妊娠率60.00% vs 55.56%(P >0.05),VC 組受精率低于 non-VC 組,差異無統計學意義.AZFc 組與 non-AZFc 組相比,受精率為57.14% vs 64.92%(P >0.05),卵裂率100% vs 99.36%(P >0.05),優質胚胎率36.36% vs 41.33%(P >0.05),纍積妊娠率66.67% vs 53.70%(P >0.05),差異均無統計學意義.結論 CBAVD 男性 ICSI 優質胚胎率和纍積妊娠率降低,VC 和AZFc 缺失對 ICSI 受精率、卵裂率、優質胚胎率和纍積妊娠率無明顯影響.
목적비교선천성쌍측수정관결여(CBAVD)、정색정맥곡장(VC)、AZFc 결실저삼충병인여상응대조주기란포장내단정자주사(ICSI)치료적결국.방법비교 CBAVD 조여비 CBAVD 적경조성무정자증(non-CBAVD 조),VC 조여비 VC 적엄중소、약정자증(non-VC 조),AZFc 결실여비 AZFc 결실적엄중소약정자증(non-AZFc 조)행 ICSI 치료적수정솔、란렬솔、우질배태솔、루적임신솔이급기타상관지표.결과각조간적녀방년령차이무통계학의의.CBAVD 조여 non-CBAVD 조비교,수정솔위61.36% vs 57.02%(P >0.05),란렬솔100% vs 99.61%(P >0.05),우질배태솔26.67% vs 48.24%(P <0.001),루적임신솔52.94% vs 80.56%(P <0.05),CBAVD 조우질배태솔화루적임신솔저우 non-CBAVD 조.VC조여 non-VC 조비교,수정솔위60.48% vs 66.03%(P >0.05),란렬솔98.02% vs 99.37%(P >0.05),우질배태솔40.40% vs 38.79%(P >0.05),루적임신솔60.00% vs 55.56%(P >0.05),VC 조수정솔저우 non-VC 조,차이무통계학의의.AZFc 조여 non-AZFc 조상비,수정솔위57.14% vs 64.92%(P >0.05),란렬솔100% vs 99.36%(P >0.05),우질배태솔36.36% vs 41.33%(P >0.05),루적임신솔66.67% vs 53.70%(P >0.05),차이균무통계학의의.결론 CBAVD 남성 ICSI 우질배태솔화루적임신솔강저,VC 화AZFc 결실대 ICSI 수정솔、란렬솔、우질배태솔화루적임신솔무명현영향.
Objective To compare the ICSI treatment outcomes of congenital bilateral absence of the vas deferens, varicocele and AZFc microdeletion with corresponding control cycles. Methods The ICSI fertilization rate, cleavage rate, good quality embryo rate, cumulative pregnancy rate and other relevant parameters were comparatively analyzed between congenital bilateral absence of the vas deferens (CBAVD group) and non-CBAVD obstructive azoospermia (non-CBAVD group), varicocele (VC group) and non- varicocele serious oligoasthenospermia (non- VC group), AZFc microdeletion and non-AZFc microdeletion serious oligoasthenospermia (non-AZFc group). Results There was no significant difference in the age of female among groups. Fertilization rates of the CBAVD group and the non-CBAVD group were 61.36% and 57.02% respectively(P> 0.05), cleavage rate were 100% and 99.61%(P> 0.05), good quality embryo rate were26.67% and 48.24% (P <0.001) , and cumulative pregnancy rate were 52.94% and 80.56% ( P<0.05)respectively. The qualified embryo rate and cumulative pregnancy rate were lower in CBAVD group than that of non-CBAVD. There were no statistical differences between VC group and non-VC group in fertilization rate ( 60.48%vs 66.03%, P>0.05), cleavage rate (98.02% vs 99.37% , P> 0.05), good quality embryo rate (40.40% vs 38.79% , P>0.05), and cumulative pregnancy rate( 60.00% vs 55.56%, P >0.05). The VC group had lower fertilization rate, with no statistical differences. There were no statistical differences between AZFc group and non-AZFc group in fertilization rate (57.14% vs 64.92%, P> 0.05), cleavage rate (100% vs 99.36%, P> 0.05), good quality embryo rate (36.36% vs 41.33% , P> 0.05) ,and and cumulative pregnancy rate(66.67% vs 53.70% , P> 0.05). Conclusion The qualified embryo rate and the cumulative pregnancy rate of CBAVD group were all decreased. No significant effect on the ICSI fertilization rate, cleavage rate, good quality embryo rate and cumulative pregnancy rate for patients with Varicocele and AZFc microdeletion.
