CAJ | 학술논문

目的探讨美罗华联合强的松治疗系统性红斑狼疮血细胞减少的临床疗效.方法选择2009年1月~2012年3月收治的系统性红斑狼疮血细胞减少患者18例,予利妥昔单抗(剂量为100mg/次,每周1次,连续4周),同时联合使用强的松(1mg/kg/d),观察疗效和不良反应.结果小剂量利妥昔单抗治疗白细胞减少及自身免疫性溶血性贫血均显示有良好的疗效,且起效迅速.18例患者中有11例达完全缓解,4例部分缓解,3例无效,显效率61.1%,有效率83.3%.结论美罗华联合强的松治疗系统性红斑狼疮血细胞减少临床效果显著,且安全、快速改善患者出血症状,值得临床推广.
목적탐토미라화연합강적송치료계통성홍반랑창혈세포감소적림상료효.방법선택2009년1월~2012년3월수치적계통성홍반랑창혈세포감소환자18례,여리타석단항(제량위100mg/차,매주1차,련속4주),동시연합사용강적송(1mg/kg/d),관찰료효화불량반응.결과소제량리타석단항치료백세포감소급자신면역성용혈성빈혈균현시유량호적료효,차기효신속.18례환자중유11례체완전완해,4례부분완해,3례무효,현효솔61.1%,유효솔83.3%.결론미라화연합강적송치료계통성홍반랑창혈세포감소림상효과현저,차안전、쾌속개선환자출혈증상,치득림상추엄.
Objective To evaluate the efficacy and side effects of mabthera and prednisone for the treatment of systemic lupus erythematosus patients with hypocytosis.Methods 18 systemic lupus erythematosus patients hypocytosis were treated with mabthera(100mg/w qw*4w) and prednisone(1mg/kg/d).The effectiveness and adverse effect were observed.Results The overall response was 83.3%(15/18),CR 61.1%(11/18),PR 22.2%(4/18),NR 16.7%(3/18).The major adverse reactions were mild,and could be tolerated.Conclusion Mabthera and prednisone is a fesible and active regimen in treatment of systemic lupus erythematosus patients with hypocytosis.