CAJ | 학술논문

目的分析结缔组织病继发肺间质病变(CTD-ILD)患者血清肿瘤标志物(TM)的水平,探讨TM与CTD-ILD的关系及其血清水平变化的机制.方法回顾性分析40例CTD-ILD患者血清TM水平及其临床资料,选取同期35例CTD无ILD患者及30名健康体检者做为疾病对照组和健康对照组.结果40例CTD-ILD患者血清TM阳性率从高至低依次为FER、CA125、CA199、CA153、CYFRA21-1、CA72-4、NSE、CEA、AFP;与健康对照组比较,CTD-ILD组患者血清FER、CA199、CA125、CA153及CA72-4水平均明显升高;与CTD组比较,CTD-ILD组患者血清FER、CA199、CA125、CA153水平均明显升高.结论 CTD-ILD患者可出现多种TM血清水平升高,其升高与全身炎症及疾病活动性关系不密切,可能主要与肺部炎症有关.
목적분석결체조직병계발폐간질병변(CTD-ILD)환자혈청종류표지물(TM)적수평,탐토TM여CTD-ILD적관계급기혈청수평변화적궤제.방법회고성분석40례CTD-ILD환자혈청TM수평급기림상자료,선취동기35례CTD무ILD환자급30명건강체검자주위질병대조조화건강대조조.결과40례CTD-ILD환자혈청TM양성솔종고지저의차위FER、CA125、CA199、CA153、CYFRA21-1、CA72-4、NSE、CEA、AFP;여건강대조조비교,CTD-ILD조환자혈청FER、CA199、CA125、CA153급CA72-4수평균명현승고;여CTD조비교,CTD-ILD조환자혈청FER、CA199、CA125、CA153수평균명현승고.결론 CTD-ILD환자가출현다충TM혈청수평승고,기승고여전신염증급질병활동성관계불밀절,가능주요여폐부염증유관.
Objective To investigate the association between serum tumor markers(TM) and connective tissue disease(CTD) with interstitial lung disease(ILD).Methods The levels of TM in serum of 30 healthy controls,35 patients of CTD without ILD and 40 patients of CTD with ILD(CTD-ILD) were tested,and the clinical data of patients with CTD-ILD were studied retrospectively.Results The positive rates of TM in 40 patients with CTD-ILD were FER(72.5%),CA125(37.5%),CA199(32.5%),CA153(25%),CYFRA21-1(17.5%),CA72-4(7.5%),NSE(7.5%),CEA(5%) and AFP(2.5%) respectively.Compared with CTD-ILD,the serum levels of FER,CA199,CA125,CA153 and CA72-4 reduced significantly in healthy controls(P<0.01),and the levels of FER(P<0.05),CA199(P<0.01),CA125(P<0.01) and CA153(P<0.01) decreased significantly in CTD without ILD too.Conclusion The serum levels of TM could increase frequently in patients with CTD-ILD,this phenomenon could correlate with the inflammation of lung tissue.