CAJ | 학술논문

目的观察水林佳联合阿拓莫兰治疗抗结核药物所致肝损伤的临床疗效.方法选择2005年1月~2012年7月住院患者89例,并随机分为治疗组45例,对照组44例,治疗组给予水林佳150mg,3次/d,阿拓莫兰1,800mg加入5%葡萄糖注射液250mL中静脉滴注,1次/d.对照组用能量合剂、肝泰乐、护肝片、甘利欣等,动态观察临床症状、体征及肝功能等情况.结果与对照组比较,治疗组主要生化指标均有明显改善,总有效率显著提高,无明显副作用.结论水林佳联用阿拓莫兰有很好的协同作用,可作为抗结核药物所致肝损伤的一种有效治疗方法.
목적관찰수림가연합아탁막란치료항결핵약물소치간손상적림상료효.방법선택2005년1월~2012년7월주원환자89례,병수궤분위치료조45례,대조조44례,치료조급여수림가150mg,3차/d,아탁막란1,800mg가입5%포도당주사액250mL중정맥적주,1차/d.대조조용능량합제、간태악、호간편、감리흔등,동태관찰림상증상、체정급간공능등정황.결과여대조조비교,치료조주요생화지표균유명현개선,총유효솔현저제고,무명현부작용.결론수림가련용아탁막란유흔호적협동작용,가작위항결핵약물소치간손상적일충유효치료방법.
Objective To observe the clinical efficacy of anti-TB drugs liver damage treated by silybin plus atomolan.Methods 89 patients in our hospital that in January 2005 to July 2012 were divided into two groups randomly,the therapeutic group(n=45),treated by silibinin capsules 150mg,3 times/day,and atomolan 1,800mg,addition of 5% glucose injection 250mL of intravenous drip,1 time/day.And the control group(n=44),treated by energy mixture,glucuronolactone,protecting liver piece,Ganlixin,dynamic observation of the clinical symptoms,signs and liver function,etc.Results The therapeutic group main biochemical indexes were obviously improved compared with those of the control group,the total effective rate significantly increased,and there is no obvious adverse effect.Conclusion Silybin plus atomolan has a very good synergy,and can be used as a kind of effective treatment methods in liver damage caused by anti-TB drugs.