CAJ | 학술논문

目的探讨血淸抗心磷脂抗体(ACL)在缺血性脑血管病(ICVD)患者发病中的作用.方法应用ELISA法检测92例ICVD患者及86名健康对照者血清中ACL含量.结果 ICVD患者ACL阳性率为29.3%(其中IgG型占74.1%、IgM型占44.4%、IgA型占25.9%),明显高于对照组(P<0.01),且ICVD组各型ACL(IgG、IgM、IgA)的平均结合指数均较对照组高(P<0.01).ICVD患者中ACL阳性组与阴性组相比,平均年龄偏小(52.7±9.2岁 vs 61.8±11.8岁,P<0.05),年轻患者(50岁以下)中ACL阳性率达47.1%;多发病灶者较多(55.6% vs 15.6%,P<0.01);反复发作情况较多(P<0.01).结论 ACL与ICVD发病密切相关,ACL阳性者更容易出现中风反复发作,是ICVD发生的危险性增高的标志.
목적탐토혈청항심린지항체(ACL)재결혈성뇌혈관병(ICVD)환자발병중적작용.방법응용ELISA법검측92례ICVD환자급86명건강대조자혈청중ACL함량.결과 ICVD환자ACL양성솔위29.3%(기중IgG형점74.1%、IgM형점44.4%、IgA형점25.9%),명현고우대조조(P<0.01),차ICVD조각형ACL(IgG、IgM、IgA)적평균결합지수균교대조조고(P<0.01).ICVD환자중ACL양성조여음성조상비,평균년령편소(52.7±9.2세 vs 61.8±11.8세,P<0.05),년경환자(50세이하)중ACL양성솔체47.1%;다발병조자교다(55.6% vs 15.6%,P<0.01);반복발작정황교다(P<0.01).결론 ACL여ICVD발병밀절상관,ACL양성자경용역출현중풍반복발작,시ICVD발생적위험성증고적표지.
Objective To investigate the roles of anticardiolipin antibody(ACL) in the pathogenesis of ischemic cerebral vascular disease(ICVD).Methods Serum ACL levels of 92 ICVD patients and 86 normal controls were measured by ELISA.Results Positive rate of ACL in ICVD patients(29.3%,IgG 74.1%,IgM 44.4%,IgA 25.9% respectively) was obviously higher than that in normal controls(P<0.01).BI of different types of ACL in ICVD group were higher versus the control group(P<0.01).Among the ICVD patients,compared with ACL negative patients,ACL positive patients were younger(52.7±9.2 years old vs 61.8±11.8 years old,P<0.05),with higher rates of multiple lesions and recurrent attacks(P<0.01).Positive rate of young patients(<50 years old) was as high as 47.1%.Conclusions ACL was closely associated with the pathogenesis of ICVD.People with positive ACL were more likely to have recurrent ischemic stroke attacks,thus ACL positive was a mark of increasing danger for ICVD occurrence.